TRIS-Based Skin Cleansing Composition for Low-Irritation Plug Removal

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Solution Overview

Problem

Existing skin cleansing compositions fail to effectively remove keratotic plugs without causing pain or irritation, and they do not adequately address pore clogging and pore opening, leading to skin roughness and darkening.

Innovation Solution

A skin cleansing composition containing 0.5 to 25% 2-amino-2-hydroxymethyl-1,3-propanediol and a pH of 8.8 to 12.2, which penetrates into keratotic plugs to elute lipids and proteins, breaking them down for thorough removal while minimizing skin burden.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional skin cleansing compositions are used to remove keratotic plugs, then pore clogging is reduced, but skin irritation and pain occur

Engineering Contradiction:
Improvekeratotic plug removal efficiencyVSAvoidskin irritation
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters of the cleansing composition by using 2-amino-2-hydroxymethyl-1,3-propanediol (TRIS) as the main active ingredient with pH controlled at 8.8-12.2. This parameter change allows effective keratotic plug removal through lipid dissolution and protein breakdown while maintaining skin compatibility, thus resolving the contradiction between removal efficiency and skin irritation.

Inventive Principle:
Principle #35Parameter changes

2Productivity

If strong keratolytic agents are used to remove keratotic plugs, then pore opening is reduced, but skin burden increases

Engineering Contradiction:
Improvepore cleaning effectivenessVSAvoidskin safety
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent uses 2-amino-2-hydroxymethyl-1,3-propanediol as an intermediary substance that mediates between the need for strong keratolytic action and skin safety. TRIS acts as a buffering agent and active ingredient that can dissolve lipids and break down proteins in keratotic plugs without causing excessive skin burden, thus resolving the contradiction between cleaning effectiveness and skin safety.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Productivity

If pH is increased to enhance keratotic plug removal, then cleaning effect improves, but skin irritation increases

Engineering Contradiction:
Improvekeratotic plug dissolution rateVSAvoidskin discomfort
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent creates a composite chemical system where 2-amino-2-hydroxymethyl-1,3-propanediol works synergistically with controlled pH (8.8-12.2). This composite approach allows the composition to achieve high keratotic plug removal efficiency through enhanced lipid dissolution and protein breakdown while the specific pH range and TRIS buffering action prevent excessive skin irritation, resolving the contradiction between cleaning effect and skin comfort.

Inventive Principle:
Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively removes keratotic plugs, reduces pore clogging, and leaves the skin soft, bright, and beautiful without causing pain or irritation.

Implementation Method 1

penetrates into keratotic plugs to elute lipids and proteins, breaking them down for thorough removal

Methodology Applied
Scientific EffectChemical dissolution:

Data Source

PatentEP3610848B1Skin cleansing composition
Publication Date: 2025.08.27 KAO CORP
  • EP3610848B1 patent drawingFigure 1
  • EP3610848B1 patent drawing
  • EP3610848B1 patent drawing

AI summary

The present invention relates to a skin cleansing composition which can sufficiently exhibit an excellent keratotic plug-removing effect without a burden, such as pain and irritation, on the skin. The skin cleansing composition comprises 0.08 mass% or more and 35 mass% or less of (X) 2-amino-2-hydroxymethyl-1,3-propanediol and has a pH of 8.6 or more and 12.5 or less at 25°C.