Trisulfide HGF Enhancers for Stronger c-Met Binding
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Solution Overview
Problem
Existing methods do not effectively enhance the physiological activity of hepatocyte growth factor (HGF) for therapeutic applications.
Innovation Solution
Trisulfide compounds, such as glutathione trisulfide and lipoic acid trisulfide, enhance the binding between HGF and its receptor c-Met, thereby increasing HGF's cell proliferation action in a concentration-dependent manner.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If HGF is used for therapeutic applications, then tissue and organ regeneration is promoted, but the physiological activity is insufficient without enhancement
Solution Approach 1:
The patent introduces trisulfide compounds as intermediary substances that mediate between HGF and its receptor c-Met. These compounds enhance the binding affinity and signaling efficiency, thereby improving physiological activity without directly acting as the therapeutic agent itself
Solution Approach 2:
The patent modifies the chemical environment by introducing trisulfide compounds that change the binding parameters between HGF and c-Met. This increases the affinity and efficiency of the HGF-c-Met interaction, leading to enhanced cell proliferation and physiological effects
2Reliability
If trisulfide compounds are added to enhance HGF activity, then binding between HGF and c-Met is improved, but the complexity of the therapeutic formulation increases
Solution Approach 1:
The trisulfide compounds serve as simple intermediary molecules that can be easily incorporated into therapeutic formulations. Their small molecular size and ability to function as binding enhancers make them practical additions without requiring complex formulation systems
Solution Approach 2:
The trisulfide compounds have multiple functions: they enhance binding affinity, improve signaling efficiency, and can be used across different therapeutic applications of HGF. This multi-functionality reduces the need for multiple separate agents, simplifying the overall formulation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The trisulfide compounds significantly boost the physiological activity of HGF, including its cell proliferation-promoting effects on various cell types and potential neuroprotective actions.
Implementation Method 1
trisulfide compounds enhance the binding between HGF and its receptor c-Met
Data Source
Figure 1(A)~1(C)
Figure 2(A)~2(B)
Figure 3a~3d
AI summary
Disclosed is an enhancer of the physiological activity of a hepatocyte growth factor, the enhancer comprising a trisulfide compound. The trisulfide compound comprises at least one component selected from the group consisting of glutathione trisulfide, a pharmaceutically acceptable salt of glutathione trisulfide, a compound represented by formula (1), a pharmaceutically acceptable salt of the compound, a cyclodextrin inclusion complex of the compound or the pharmaceutically acceptable salt, a compound represented by formula (6), a pharmaceutically acceptable salt of the compound, and a cyclodextrin inclusion complex of the compound or the pharmaceutically acceptable salt.