Trocar Stabilization for Extravascular Therapeutic Delivery
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Solution Overview
Problem
Current cell therapy delivery methods face challenges in maintaining positional stability during extravascular delivery, leading to inefficient distribution and short residence time of therapeutic cellular material at the target site due to patient movement and trauma caused by delivery instruments.
Innovation Solution
A device with metered infusion capabilities and a stabilizing mechanism, including a trocar with engagement components and a compressive spring section, is used to deliver therapeutic agents extravascularly to target locations within a patient, maintaining stability and preventing extravasation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If extravascular delivery is performed without stabilization, then delivery efficiency is improved, but positional stability deteriorates due to patient movement and instrument trauma
Solution Approach 1:
The trocar is inserted and positioned into the target tissue before the actual therapeutic agent delivery begins. This preliminary positioning and stabilization of the delivery instrument ensures that subsequent injection or infusion operations occur from a stable, pre-established position, preventing movement-related issues during the therapeutic delivery process.
Solution Approach 2:
The trocar serves as an intermediary instrument between the external delivery device and the internal target tissue. It provides a stable conduit and anchoring point that mediates the connection, allowing therapeutic agents to be delivered accurately while the trocar itself remains stabilized within the tissue to prevent positional drift or trauma.
2Duration of action of moving object
If rapid delivery is performed, then residence time is improved, but delivery efficiency deteriorates due to flushing effects
Solution Approach 1:
The delivery system employs periodic or controlled intermittent delivery of therapeutic agents rather than continuous rapid infusion. This periodic action allows the therapeutic material to be delivered in controlled pulses or intervals, enabling adequate residence time at the target site while preventing the harmful flushing effect that would occur with continuous rapid delivery. The rhythm of delivery matches the physiological retention capacity of the target tissue.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures stable and efficient delivery of therapeutic agents, such as cells or exosomes, to target sites like the kidney or tumors, enhancing residence time and delivery efficiency while minimizing trauma and movement-related issues.
Implementation Method 1
a compressive spring section, is used to deliver therapeutic agents extravascularly to target locations within a patient, maintaining stability
Data Source
AI summary
Provided herein are, inter alia, devices, methods, and systems are provided for delivering pharmaceutical fluid formulations, such as with metered infusion capabilities delivered extravascularly to target locations within a patient while maintaining positional stability. An exemplary device can be configured to deliver non-continuous streams or boluses of fluid to a target site. In certain embodiments, the injection device can engage with an exemplary trocar that is configured to have one or more stabilization mechanisms on a shaft thereof such that the trocar provides a stable delivery mechanism to the injection device. The trocar is configured to receive an injection needle therein that is attached to the injection device, and the injection device can deliver fluid therethrough to a target tissue site.