Tropolone Antimicrobial Composition with Bio-Derived Solvents
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Solution Overview
Problem
Current antimicrobial compositions face limitations due to toxicity, irritation potential, and regulatory constraints, particularly in the food and personal care industries, necessitating the development of eco-friendly, non-aqueous solutions with reduced solvent concentrations that effectively inhibit microbial growth without adverse environmental impact.
Innovation Solution
A stable, eco-friendly antimicrobial composition comprising 0.1 wt% to 20 wt% Tropolone combined with 80 wt% to 99.9 wt% of bio-derived solvents such as 1,3-propanediol or sorbitan caprylate, which demonstrates synergistic antimicrobial activity against gram (+) bacteria, gram (-) bacteria, yeasts, and fungi, and is suitable for various applications including cosmetics, toiletries, and food products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ethylene glycol is used as a preservative, then preservation effectiveness is improved, but toxicity increases
Solution Approach 1:
The patent replaces persistent toxic preservatives like ethylene glycol with biodegradable alternatives such as 1,3-propanediol and sorbitan caprylate. These bio-derived solvents provide effective preservation while being environmentally friendly and non-toxic, allowing the preservative system to be 'disposed of' harmlessly through biodegradation.
Solution Approach 2:
The patent changes the chemical composition parameters by transitioning from petrochemical-based glycols to bio-based alternatives. Specifically, it uses 1,3-propanediol with bio-based carbon content of 1% to 100% and sorbitan caprylate, fundamentally altering the preservative system's toxicity profile while maintaining preservation efficacy.
2Object-affected harmful factors
If chemically synthesized propylene glycol is used, then non-toxicity is improved, but irritation potential and harmful impurities increase
Solution Approach 1:
The patent replaces chemically synthesized propylene glycol with biodegradable bio-based alternatives like 1,3-propanediol and sorbitan caprylate. These natural derivatives provide the necessary preservation function while being harmless to the environment and free from synthetic impurities, allowing safe degradation after use.
Solution Approach 2:
The patent fundamentally changes the source and composition parameters by using bio-based solvents with specific natural origins. The 1,3-propanediol is derived from renewable resources with controlled bio-based carbon content, and sorbitan caprylate is used as a natural alternative, eliminating the harmful synthetic impurities associated with chemical synthesis.
3Reliability
If higher concentration of alcohols is used, then antimicrobial activity is improved, but viscosity lowering increases
Solution Approach 1:
The patent changes the physical state parameters by using non-aqueous bio-based solvents instead of traditional alcohols. The 1,3-propanediol and sorbitan caprylate provide the necessary solvation and antimicrobial properties without the excessive viscosity reduction caused by high alcohol concentrations, maintaining product stability.
4Reliability
If higher concentration of antimicrobial active ingredients is used, then preservation effectiveness is improved, but side effects increase
Solution Approach 1:
The patent introduces bio-based solvents (1,3-propanediol and sorbitan caprylate) as intermediary substances that enhance the effectiveness of lower concentrations of antimicrobial actives. These solvents act as mediators that improve the performance and stability of the preservative system, allowing reduced levels of active ingredients while maintaining or enhancing preservation effectiveness and reducing side effects.
Data Source
AI summary
Disclosed herein is an eco-friendly, non-aqueous and stable antimicrobial solution composition comprising (a) about 0.1 to 20.0 wt% of a Tropolone; and (b) about 80.0 to 99.9 wt% of bio-derived 1,3-propanediol and/or bio-derived sorbitan caprylate. Also disclosed is a process for preparing and method of using the composition. The composition is stable for at least two years at room temperature and can be employed in the fields of cosmetic, toiletry, personal care, household, cleaning, disinfecting, food, beverages, enzyme formulations, feminine care products, foot care products, pet care products, food ingredients, paints, coatings, metal working fluids, nutrients for plants, construction and/or laundry products.