L-Tryptophan Ester Derivatives for Dual Deodorant and Perfume Action

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Solution Overview

Problem

Current deodorant and antiperspirant products often disrupt skin flora and have drawbacks such as modifying the skin's ecology, and there is a need for novel ingredients that can effectively treat body odor while also providing a perfuming action without these limitations.

Innovation Solution

The use of ester derivatives of L-tryptophan, specifically compounds with formulas (I), (II), and (III), which exhibit both deodorant activity and perfuming properties, can be used alone or in combination with antiperspirant and deodorant agents in cosmetic compositions to treat body odor and provide a pleasant scent.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional deodorant substances (Triclosan, farnesol) are used to destroy bacterial flora and reduce body odor, then deodorant efficacy is improved, but skin flora ecology is significantly modified

Engineering Contradiction:
Improvedeodorant efficacyVSAvoidskin flora modification
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters of deodorant agents by using ester derivatives of L-tryptophan with specific molecular structures (formulas I, II, III) instead of conventional Triclosan or farnesol. These new compounds have different biochemical properties that allow them to reduce body odor through alternative mechanisms that do not significantly disrupt skin flora ecology.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs composite deodorant compositions containing multiple ester derivative compounds with different R groups (as defined in formulas I, II, III), combining them with antiperspirant agents and other deodorant substances. This composite approach creates a synergistic effect that maintains deodorant efficacy while reducing harmful impacts on skin flora.

Inventive Principle:
Principle #40Composite materials

2Reliability

If transition metal chelating agents (EDTA, DPTA) are used to reduce bacterial growth by depriving metals, then bacterial growth is reduced, but metal availability for skin functions is affected

Engineering Contradiction:
Improvebacterial growth controlVSAvoidmetal deprivation
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent extracts the deodorant function from metal-chelating mechanisms and implements it through ester derivatives of L-tryptophan. These compounds reduce body odor through direct biochemical interactions with odor-causing compounds or bacteria without requiring metal chelation, thereby eliminating the harmful metal deprivation effect while maintaining bacterial growth control.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The ester derivatives of L-tryptophan act as intermediary substances that mediate between the skin environment and odor-causing bacteria. They provide essential functions (odor reduction, bacterial control) through alternative biochemical pathways that do not involve metal chelation, thus avoiding the harmful effects of metal deprivation.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Reliability

If perfume is added to mask unpleasant odors, then odor masking is improved, but product complexity increases

Engineering Contradiction:
Improveodor maskingVSAvoidproduct formulation
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The ester derivatives of L-tryptophan exhibit dual functionality: they provide deodorant activity by reducing body odor through biochemical mechanisms, and simultaneously provide perfuming action with pleasant scents. This multi-functionality eliminates the need to separately add perfume components, thereby maintaining odor masking efficacy while simplifying the overall product formulation.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent merges the deodorant function and perfuming function into a single compound class (ester derivatives of L-tryptophan). By combining these two previously separate functions into one active ingredient system, the formulation complexity is reduced while maintaining both odor reduction and pleasant scent properties.

Inventive Principle:
Principle #5Merging (Combining)

Data Source

PatentUS11517516B2Use of ester derivative of tryptophan as deodorant and/or perfume agent
Publication Date: 2022.12.06 LOREAL SA
  • US11517516B2 patent drawing
  • US11517516B2 patent drawing
  • US11517516B2 patent drawing

AI summary

This invention relates to the use of at least one following compound having formula (I), as well as the salts thereof, the optical and geometric isomers thereof, and the solvates thereof, as deodorant agent for treating body odor, preferably underarm odor: