Tryptophan Peptide Composition for Stable Brain Uptake
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Solution Overview
Problem
Current formulations fail to effectively deliver tryptophan to the brain due to competitive uptake by other amino acids, leading to insufficient brain uptake and potential allergic reactions from large peptides, while also experiencing fluctuations in blood glucose levels that hinder optimal brain function and mood benefits.
Innovation Solution
A formulation comprising tryptophan-containing peptides with a high tryptophan/LNAA ratio, combined with rapidly and slowly available glucose, to enhance tryptophan uptake and maintain stable blood glucose levels, utilizing hydrolyzed lysozyme and specific peptide ratios to achieve improved bioavailability and reduced allergenicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If tryptophan-rich proteins or free amino acids are used, then tryptophan uptake by the brain is improved, but competitive uptake by other amino acids reduces effectiveness and food legislation limits use of free amino acids
Solution Approach 1:
The patent segments tryptophan delivery from competing amino acids by using tryptophan-containing peptides where tryptophan is bound in specific peptide sequences. This segmentation allows tryptophan to be delivered to the brain without the competing large neutral amino acids that would be present in free amino acid formulations or whole proteins, thereby resolving the contradiction between achieving high brain uptake and complying with food legislation.
Solution Approach 2:
The patent extracts tryptophan from the context of competing amino acids by using specific peptide sequences that contain tryptophan but exclude or minimize other large neutral amino acids. This extraction approach allows the formulation to achieve high tryptophan/LNAA ratios while maintaining compliance with food regulations that restrict free amino acid use.
2Quantity of substance
If tryptophan is delivered as free amino acid, then brain uptake is enhanced, but food legislation in many countries limits the use of free amino acids in foodstuffs
Solution Approach 1:
The patent changes the chemical form parameter of tryptophan from free amino acid to peptide-bound tryptophan in specific sequences. This parameter change allows the formulation to bypass food legislation restrictions on free amino acids while maintaining high tryptophan availability for brain uptake, as the tryptophan is delivered within peptide structures that are permitted in foodstuffs.
3Quantity of substance
If rapidly digestible carbohydrates are used to stimulate insulin and increase tryptophan uptake, then brain tryptophan levels improve, but blood glucose fluctuations occur that may hinder optimal brain function
Solution Approach 1:
The patent employs a periodic or staged carbohydrate digestion approach by combining rapidly digestible carbohydrates (for initial insulin stimulation) with slowly digestible carbohydrates (for sustained glucose release). This periodic action pattern allows initial tryptophan uptake stimulation followed by stable glucose maintenance, resolving the contradiction between enhancing tryptophan delivery and maintaining glucose stability for optimal brain function.
Data Source
AI summary
An edible composition comprising peptides rich in tryptophan, which edible composition further comprises a rapidly available glucose composition and a slowly available glucose composition.