Tryptophol and 4-Ethyl-Phenol Derivatives Modulate Gut Microbiome
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Solution Overview
Problem
There is a need for methods to modulate microbial populations in hosts to increase the abundance and diversity of beneficial microorganisms, particularly in cases of inflammation and other deficiencies where these are reduced, such as in inflammatory diseases and Vitamin D deficiency.
Innovation Solution
A combination of Tryptophol derivatives and 4-Ethyl-Phenol derivatives is used to modulate the microbial population by increasing the abundance and diversity of Odoribacteraceae and reducing pathogenic bacteria like Vibrio cholerae, salmonella enterica, and staphylococcus aureus, administered through a composition that may include a microorganism mixture like kefir.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If probiotic microorganisms are administered to increase beneficial bacterial abundance, then the diversity and abundance of beneficiary microorganisms is increased, but the complexity of modulating specific microbial populations remains challenging
Solution Approach 1:
The patent uses small molecules (tryptophol derivative and 4-ethyl-phenol derivative) to change the chemical parameters of the gut environment, which selectively promotes the growth of Odoribacteraceae bacteria. This approach transforms the complex biological problem of microbiome modulation into a more manageable chemical parameter adjustment problem, where specific molecular compounds can be administered to achieve desired microbial population changes without requiring complex delivery systems or multiple probiotic strains.
2Quantity of substance
If conventional probiotics are used to treat inflammatory diseases, then general microbial abundance may increase, but the specific reduction of pathogenic bacteria like Vibrio cholerae, salmonella enterica, and staphylococcus aureus is insufficient
Solution Approach 1:
The patent introduces small molecules (tryptophol derivative and 4-ethyl-phenol derivative) as intermediary substances that mediate between the host and microbial populations. These molecules act as signaling compounds that selectively influence bacterial behavior and growth - promoting beneficial Odoribacteraceae while simultaneously suppressing pathogenic bacteria. This intermediary approach allows for more precise control over microbial community composition compared to direct probiotic administration alone.
Data Source
AI summary
The present invention is directed to compositions comprising a Tryptophol derivative, a 4-Ethyl-Phenol derivative, or a combination thereof, and methods of using same, such as for modulating abundance, diversity, or both, of a microbial population tin a subject in need thereof.