Real-time Tumor Segmentation via Region-Based Morphological Analysis

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Solution Overview

Problem

Current methods for tumor segmentation in radiation therapy are time-consuming and prone to errors, especially during real-time tracking of tumor motion, which limits the precision of radiation delivery and requires extensive manual or semiautomatic processes that are not efficient with advanced imaging systems like real-time MR imaging.

Innovation Solution

An automatic segmentation technique that rapidly divides imaging data into regions based on value similarity, using area filtering and morphological operators to identify tumors, allowing for real-time correction of radiation beam placement during treatment sessions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If manual or semiautomatic segmentation methods are used to identify tumor boundaries on multiple image slices, then segmentation accuracy can be maintained, but the process becomes extremely time-consuming and cannot keep pace with real-time imaging capabilities

Engineering Contradiction:
Improvesegmentation accuracyVSAvoidsegmentation speed
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The system uses the imaging system itself to automatically identify tumor boundaries by analyzing image data and detecting tissue characteristics, eliminating the need for manual intervention. The computer automatically segments tumors by processing imaging data and identifying boundary characteristics without requiring healthcare professional input for each image slice.

Inventive Principle:
Principle #25Self-service

2Productivity

If automatic segmentation techniques such as thresholding, region growing, clustering, and neural networks are used to increase processing speed, then productivity improves, but measurement precision and reliability of tumor identification deteriorate

Engineering Contradiction:
Improvesegmentation speedVSAvoidtumor identification accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The system applies different processing characteristics to different regions of the image data. It identifies specific tissue characteristics and boundary features locally within the imaging data, analyzing unique properties of tumor tissues versus surrounding healthy tissue. This localized analysis maintains high precision by adapting to the specific characteristics of each tumor region rather than applying uniform automatic segmentation algorithms.

Inventive Principle:
Principle #3Local quality

3Ease of manufacture

If the radiation treatment plan is prepared from images obtained prior to treatment, then treatment planning can be completed, but tumor position uncertainties during treatment reduce the accuracy of dose placement

Engineering Contradiction:
Improvetreatment plan preparationVSAvoiddose placement accuracy
Core Design Contradiction:
Ease of manufactureVSManufacturing precision

Solution Approach 1:

The system continuously monitors tumor position during radiation treatment by processing real-time imaging data acquired during the treatment session. The computer analyzes each new image to detect tumor location and boundaries, then feeds this information back to adjust the radiation beam positioning and dosing in real-time, ensuring accurate dose delivery despite tumor motion or position changes.

Inventive Principle:
Principle #23Feedback

Data Source

PatentUS8992405B2High-speed tumor segmentation system
Publication Date: 2015.03.31 WISCONSIN ALUMNI RES FOUND
  • US8992405B2 patent drawing
  • US8992405B2 patent drawing
  • US8992405B2 patent drawing

AI summary

A system for automatic segmentation of tumor tissue, useful for motion correction during radiotherapy using real-time imaging, identifies multiple regions based on the values of data and then identifies the tumors within the regions based on a priori knowledge about tumor size and/or location. The regions may be refined with robust and fast morphological operations, providing segmentation at speeds commensurate with the motion to be corrected.