Twist-Activated Sample Valve for Ambient Biomolecule Preservation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing biological sample collection systems face challenges in maintaining the integrity of biomolecules under ambient conditions, especially for remote collection and transportation, and require user-friendly designs for novice users, while ensuring safe handling and storage of preservatives.
Innovation Solution
A biological sample collection system with a twist-activated valve that separates a sample collector and storage chamber, allowing for safe storage and mixing of biological samples with stabilizing compositions at ambient temperatures, using a twist mechanism to open and close the valve for fluid communication.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If biological samples are stored under freezing temperatures to maintain biomolecule integrity, then the stability of biomolecules is improved, but the cost, complexity, and impracticality of transportation and storage increase
Solution Approach 1:
The invention changes the temperature parameter from freezing to ambient, and introduces a chemical preservative parameter to stabilize biomolecules. The collection device includes a preservative chamber that releases stabilizing chemicals (e.g., denaturants like guanidine thiocyanate) into the sample at ambient temperature, preventing biomolecule degradation without requiring freezing conditions.
Solution Approach 2:
The invention introduces a preservative substance as an intermediary between the biological sample and the storage environment. The preservative chamber contains and controls the release of chemical agents that protect biomolecules from degradation, serving as a mediator that enables stable storage at ambient temperatures instead of requiring direct freezing of the sample.
2Object-affected harmful factors
If preservatives are kept separate from the sample until use, then user safety is improved, but the device complexity increases
Solution Approach 1:
The invention divides the collection device into separate functional chambers: a sample collection chamber and a preservative storage chamber. The preservative chamber is a distinct segmented component that can be separately manufactured, filled, and sealed, then integrated with the collection device. This segmentation isolates the toxic preservative from the user during normal operation while maintaining system functionality.
Solution Approach 2:
The preservative chamber is nested within or integrated into the overall collection device structure. The preservative chamber fits inside or alongside the sample collection chamber, creating a compact nested arrangement that protects the preservative while enabling controlled interaction with the sample through valve mechanisms.
3Reliability
If a valve mechanism is added to control sample release, then sample integrity is improved, but the ease of operation for novice users decreases
Solution Approach 1:
The valve mechanism is designed as a dynamic component that responds to user actions (twisting or pressing) to transition between open and closed states. The valve stem moves dynamically within the valve seat, allowing controlled sample release when needed while maintaining sealing when closed. This dynamic design enables reliable control without requiring complex manual manipulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system maintains biomolecule integrity and safety by allowing easy sample collection and transportation without specialized personnel, enabling mixing with preservatives only when needed, thus preserving the sample and protecting users from harmful substances.
Implementation Method 1
The sample collection assembly includes a threaded connection member disposed at the distal open end of the sample collector... The threaded connection member is complementary to and configured to be engaged with the threaded connection member of the sample collection vessel
Data Source
AI summary
A biological sample collection system comprising a containment vessel and a sample collection assembly connected thereto is provided. The assembly comprises a sample collector threadedly engaged with a sample collection vessel having a sample receiving area for receiving the biological sample from the sample collector. The collector comprises a valve stem comprising a valve face, and the collection vessel comprises a complementary valve seat. The valve stem and valve seat form a valve comprising a closed configuration wherein threaded connection members of the collector and the collection vessel are fully engaged, and an open configuration wherein the threaded connection members are less than fully engaged. In the closed configuration, the valve face forms a sealing engagement with the valve seat. In the open configuration, the valve face is spaced apart from the valve seat to place the containment vessel, collection vessel, and collector in fluid communication with one another.