Two-Component Sealant System for Organ Resection
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Solution Overview
Problem
Current methods for sealing resected tissue surfaces during surgical procedures are inadequate in preventing bleeding, fluid leaks, and air leaks due to issues with adhesion, elasticity, and visibility, particularly in organs like the liver and lungs, where traditional adhesives and meshes fail to provide a reliable, airtight seal.
Innovation Solution
A two-component sealant system comprising a synthetic matrix made of polyglactin 910 and a biosynthetic adhesive, such as albumin and PEG-SG, which forms a flexible, porous, and transparent barrier that adheres to the tissue, providing mechanical and chemical cross-linking for a secure seal.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If adhesive fluids (synthetic adhesives, fibrin glue) are used to seal resected surfaces, then bleeding and fluid leakage are managed, but the adhesive flows off the resected surface prior to curing or peels off after curing due to lack of adequate adherence or proper elastic properties
Solution Approach 1:
The patent combines a synthetic mesh (providing structural framework and elasticity) with adhesive fluid (providing bonding capability) to create a composite sealing system. The mesh acts as a reinforcement that prevents adhesive flow-off while the adhesive provides tissue bonding, resolving the contradiction between sealing reliability and adhesive strength.
Solution Approach 2:
The synthetic mesh provides a flexible structural framework that conforms to the resected surface and maintains elastic properties. This flexible shell structure prevents the adhesive from flowing off while allowing the system to adapt to tissue movement, thereby improving both adhesive strength and sealing reliability.
2Object-affected harmful factors
If traditional adhesives and meshes are used for sealing, then bleeding is controlled, but the seal is not airtight due to intrinsic friability of lung parenchyma and inadequate adherence
Solution Approach 1:
The combination of synthetic mesh and adhesive fluid creates a composite system that addresses the friability of lung tissue. The mesh provides a robust structural framework that can accommodate fragile tissue while the adhesive ensures secure bonding, together creating an airtight seal that traditional single-material approaches cannot achieve.
Solution Approach 2:
The system applies different properties to different components: the synthetic mesh provides structural strength and elasticity locally at the seal site, while the adhesive fluid provides chemical bonding capability. This local differentiation of material properties allows the system to overcome the inherent friability of lung parenchyma and create reliable airtight seals.
3Reliability
If extensive suturing and tourniquets are used to manage bleeding, then major bleeding is controlled, but the procedures are complex and time-consuming
Solution Approach 1:
The patent extracts the hemostatic function from complex procedures like extensive suturing and tourniquets, and concentrates it into a single applied composite material system. The synthetic mesh with adhesive fluid directly seals the resected surface, eliminating the need for multiple separate hemostatic measures and reducing procedure complexity while maintaining reliable hemostasis.
Solution Approach 2:
The synthetic mesh-adhesive fluid composite system performs multiple functions simultaneously: it provides structural support, enables adhesive bonding, ensures elastic properties, and achieves hemostasis. This multi-functionality replaces what would traditionally require separate sutures, tourniquets, and adhesives, thereby reducing procedure complexity while maintaining comprehensive hemostatic control.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively prevents bleeding, fluid leaks, and air leaks by forming a strong, flexible, and transparent seal that withstands pressure, allowing for better visualization and tissue conformability, thus reducing post-operative complications.
Implementation Method 1
a biosynthetic adhesive, such as albumin and PEG-SG, which forms a flexible, porous, and transparent barrier that adheres to the tissue, providing mechanical and chemical cross-linking for a secure seal
Data Source
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AI summary
A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.