Two-Fluid Nozzle Gas Circulation for Heated Intraperitoneal Chemotherapy
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing intraperitoneal chemotherapy methods face challenges in maintaining a temperature of 42°C in the peritoneal cavity, uneven drug distribution, and difficulty in adjusting the spraying direction, leading to reduced efficacy and increased side effects.
Innovation Solution
A system comprising a gas circulation device with a temperature control mechanism and a drug-and-gas spray device, utilizing a two-fluid nozzle to circulate and spray hyperthermic pressurized gas and anticancer drugs at a set temperature and pressure, ensuring even distribution and controlled direction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If PIPAC is used to spray nebulized drug directly to cancer cells, then chemotherapy effect is achieved with about 10% of the anticancer drug dosage used in HIPEC, but the temperature in the peritoneal cavity is difficult to maintain at 42°C due to temperature homeostasis
Solution Approach 1:
The patent introduces a heating element as an intermediary device that heats the gas before it enters the peritoneal cavity. This mediator allows the system to overcome the body's temperature homeostasis mechanism by continuously supplying heated gas, thereby maintaining the therapeutic temperature of 42°C despite the body's natural cooling response.
Solution Approach 2:
The patent changes the temperature parameter of the circulating gas from normal body temperature to hyperthermic temperature (42°C). By controlling the temperature parameter of the gas phase, the system achieves therapeutic hyperthermia while using reduced doses of anticancer drugs, resolving the contradiction between drug dosage and temperature maintenance.
2Temperature
If HIPEC is used to maintain temperature at about 42°C, then temperature is maintained at therapeutic level, but chemotherapy side effects occur due to large amount of anticancer drug and extensive surgical procedure
Solution Approach 1:
The patent extracts the heating function from the traditional HIPEC surgical procedure and implements it through a separate, controllable heating system that circulates heated gas. This allows temperature maintenance without requiring extensive surgical intervention, thereby reducing chemotherapy side effects while maintaining therapeutic temperature.
Solution Approach 2:
The patent changes the drug dosage parameter by utilizing hyperthermic conditions (42°C) that enhance drug efficacy, allowing the use of reduced anticancer drug doses. This parameter change in temperature enables therapeutic effect with lower drug quantities, thereby reducing chemotherapy side effects.
3Quantity of substance
If existing methods are used to spray anticancer drug, then drug is administered to peritoneal cavity, but anticancer drug is difficult to be evenly sprayed and spraying direction is difficult to adjust
Solution Approach 1:
The patent implements a dynamic spray system where the nozzle can be positioned and directed within the peritoneal cavity. The spray device is designed to move and adjust its orientation, allowing the operator to dynamically control the spraying direction and ensure even distribution of the anticancer drug throughout the target area.
Solution Approach 2:
The patent introduces a gas flow field as an intermediary medium that carries the nebulized anticancer drug throughout the peritoneal cavity. This gas mediator enables even distribution of the drug by utilizing gas flow patterns that disperse the medication uniformly, while the spray direction can be adjusted by controlling the gas flow and nozzle positioning.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively maintains a set temperature in the peritoneal cavity, allows for even distribution of the anticancer drug, and maximizes chemotherapy efficacy by nebulizing the drug to metastasized cancer cells.
Implementation Method 1
a heater that heats the gas hose
Implementation Method 2
a two-fluid nozzle through which a drug such as an anticancer drug is effectively sprayed in a peritoneal cavity
Data Source
AI summary
Disclosed are: a system comprising a gas circulation device capable of circulating hyperthermic gas in the peritoneal cavity and a temperature control device; and a system comprising a drug spray device for effectively spraying a drug in the peritoneal cavity together with gas. The systems of the present invention are used as systems for hyperthermic intraperitoneal chemotherapy and can maximize the anticancer therapy effect by more effectively delivering a small amount of an anticancer drug to cancer cells while maintaining the temperature of gas in the peritoneal cavity at a predetermined temperature.