Two-Layer Denture Base Reducing Candida Adhesion

Solution Overview

Problem

Current dental materials for dentures often compromise on mechanical strength and translucency when antimicrobial components are added, leading to issues like Candida adhesion and aesthetic concerns.

Innovation Solution

A two-layer dental restoration base material is developed, with a first layer comprising a high percentage of (meth)acrylic polymer and monomer, and a surface layer containing 0.1 to 5 wt.% antimicrobial nanoparticles, primarily silver or zirconium dioxide, to reduce Candida adhesion and maintain mechanical properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If silver nanoparticles are added to acrylic resin to improve antimicrobial resistance, then Candida adhesion is reduced, but mechanical strength and translucency deteriorate

Engineering Contradiction:

Improveantimicrobial resistanceVSAvoidmechanical strength

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The denture base is divided into two distinct layers: a first layer without nanoparticles providing mechanical strength and translucency, and a second surface layer containing silver nanoparticles providing antimicrobial resistance. This segmentation allows each layer to optimize its specific function without compromising the other properties.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The antimicrobial nanoparticles are localized specifically in the second surface layer that contacts the oral environment, while the first layer maintains pure acrylic resin properties for mechanical support. This local concentration of antimicrobial agents provides protection where needed without affecting overall structural integrity.

Inventive Principle:

Principle #3Local quality

2Reliability

If silver nanoparticles are added to acrylic resin to improve antimicrobial resistance, then Candida adhesion is reduced, but color stability deteriorates

Engineering Contradiction:

Improveantimicrobial resistanceVSAvoidcolor stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The denture base is divided into two distinct layers: a first layer without nanoparticles providing mechanical strength and translucency, and a second surface layer containing silver nanoparticles providing antimicrobial resistance. This segmentation allows each layer to optimize its specific function without compromising the other properties.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The antimicrobial nanoparticles are localized specifically in the second surface layer that contacts the oral environment, while the first layer maintains pure acrylic resin properties for mechanical support. This local concentration of antimicrobial agents provides protection where needed without affecting overall structural integrity.

Inventive Principle:

Principle #3Local quality

3Reliability

If a single-layer structure with antimicrobial nanoparticles is used, then antimicrobial resistance is improved, but manufacturing complexity increases

Engineering Contradiction:

Improveantimicrobial resistanceVSAvoidmanufacturing complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The denture base is divided into two distinct layers: a first layer without nanoparticles providing mechanical strength and translucency, and a second surface layer containing silver nanoparticles providing antimicrobial resistance. This segmentation allows each layer to optimize its specific function without compromising the other properties.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The first layer is formed first as a base structure, and then the second layer with nanoparticles is applied on top. This sequential approach allows for controlled manufacturing where each layer can be processed independently before combining them, simplifying the overall production process.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The two-layer structure effectively reduces Candida adhesion by up to 95% and enhances flexural strength while maintaining translucency and surface roughness within clinically acceptable limits, improving the overall performance of denture materials.

Implementation Method 1

the bacterial toxicity, or bactericidal activity, of silver nano-material fillers is mainly due to damage of cell membrane and disruption of ion homeostasis

Methodology Applied

Scientific EffectCell membrane damage:

Implementation Method 2

a surface layer comprising at least 90 wt. % of a cured second composition comprising a second (meth)acrylic polymer, a second (meth)acrylic monomer, and 0.1 to 5 wt. % of antimicrobial nanoparticles

Methodology Applied

Scientific EffectAntimicrobial adhesion reduction:

Implementation Method 3

a first layer comprising at least 90 wt. % of a cured first composition comprising a first (meth)acrylic polymer and a first (meth)acrylic monomer

Methodology Applied

Scientific EffectPolymerization:

Data Source

PatentUS20250017826A1Method of forming a denture stomatitis reduction device

Publication Date: 2025.01.16 IMAM ABDULRAHMAN BIN FAISAL UNIV

AI summary

Base material arrangements having at least two layers can accommodate the addition of antifungal material (nanofiller), such as in denture base resin without significantly compromising the mechanical properties and/or translucency of the base material arrangements. Antifungal agents such as nanosilver and nanozirconia can be used to modify a surface layer of the material arrangements, such as the denture base, to overcome certain known shortcomings of the modified materials, e.g., typical acrylic resins containing nanosilver and nanozirconia.