Two-Phase Endoscope Registration for Multi-Device Lesion Localization

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Solution Overview

Problem

Current surgical procedures involving multiple endoscopic devices, such as bronchoscopy with endobronchial ultrasound (EBUS) for lung cancer diagnosis, face challenges due to the lack of effective tools for coordinating and guiding the use of these devices, leading to inaccurate lesion localization and low biopsy success rates, especially for extraluminal lesions.

Innovation Solution

A methodology and system for guiding surgical procedures using an endoscope and a second complementary device, like EBUS, by integrating virtual anatomical views and graphical cues from patient imaging scans to derive a pre-operative procedure plan, providing real-time guidance through simulated video views and registration methods to synchronize the devices accurately.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If a physician uses multiple endoscopic devices (e.g., bronchoscope and EBUS probe) to examine extraluminal lesions, then the diagnostic capability for peripheral lung lesions is improved, but the coordination difficulty and procedural complexity increase significantly

Engineering Contradiction:
Improvediagnostic capabilityVSAvoidcoordination difficulty
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent introduces a computational guidance system as an intermediary that mediates between the physician and the complex multi-device coordination task. The system processes images from multiple devices, registers them to a common coordinate system, and provides automated guidance cues that simplify the physician's coordination burden while maintaining full diagnostic capability.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates virtual copies of the physical devices and their coordinate systems in a computational model. By registering virtual representations of the bronchoscope, EBUS probe, and other devices to a common reference frame, the system enables precise spatial relationship reconstruction without requiring the physician to manually coordinate all devices in real-time.

Inventive Principle:
Principle #26Copying

2Ease of operation

If a physician manually coordinates multiple endoscopic devices without guidance tools, then the procedural flexibility is maintained, but the measurement precision of lesion localization deteriorates

Engineering Contradiction:
Improveprocedural flexibilityVSAvoidlesion localization accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The system continuously processes images from multiple devices, registers them to the common coordinate system, and provides real-time feedback to the physician through guidance cues. This feedback loop enables the physician to maintain procedural flexibility while achieving precise lesion localization through automated spatial relationship computation.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent performs preliminary registration of device coordinate systems and pre-computation of spatial relationships before the actual lesion examination. This preliminary action establishes an accurate computational model that guides subsequent procedures, ensuring measurement precision without restricting procedural flexibility during execution.

Inventive Principle:
Principle #10Preliminary action

3Adaptability or versatility

If a physician relies on skill and dexterity to coordinate multiple devices, then the adaptability to different cases is maintained, but the reliability of lesion localization varies greatly

Engineering Contradiction:
Improvecase adaptabilityVSAvoidlocalization consistency
Core Design Contradiction:
Adaptability or versatilityVSReliability

Solution Approach 1:

The computational guidance system performs self-service by automatically processing images, registering devices to the common coordinate system, and generating guidance cues without requiring physician intervention in the coordination process. This automation maintains case adaptability through automated image processing while significantly improving localization reliability through consistent computational methods.

Inventive Principle:
Principle #25Self-service

4Manufacturing precision

If a guidance system integrates virtual anatomical views and graphical cues from imaging scans, then the manufacturing precision of device positioning is improved, but the device complexity and system requirements increase

Engineering Contradiction:
Improvedevice positioning accuracyVSAvoidsystem requirements
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent implements a universal computational platform that handles multiple functions: processing images from various device types, registering different coordinate systems, visualizing anatomical structures, and providing guidance cues. This multi-functional approach achieves high positioning precision while managing system complexity through a single integrated architecture rather than separate specialized systems.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS12349859B2Two-phase instrument guidance for accurate endoscopic surgical procedures
Publication Date: 2025.07.08 THE PENN STATE RES FOUND INC
  • US12349859B2 patent drawing
  • US12349859B2 patent drawing
  • US12349859B2 patent drawing

AI summary

A two-stage method for guiding an endoscope and second device toward a target destination near the ROI includes navigation and localization. The endoscope is navigated near the vicinity of the ROI according to a pre-procedure plan. When the ROI location is reached, the second device's tip is pushed far enough through the endoscope so that its tip is outside the endoscope and in the endoscope's video view. Then a two-phase registration mechanism is used: i. Phase 1: Align the endoscope by registering the endoscope's video to a virtual bronchoscope's simulated video stream; ii. Phase 2: Align the second device by registering the second device's shape in the endoscope's video to a virtual second device model.