Two-Phase Oral Care Composition for Stable Peracetic Acid Whitening
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Solution Overview
Problem
Conventional oral care products using hydrogen peroxide for teeth whitening often require longer treatment times due to varying oxidation rates of different chromophores, and highly reactive whitening agents are unstable and degrade quickly, reducing their effectiveness.
Innovation Solution
An oral care composition comprising a hydrophobic phase with hydrogen peroxide and an acyl donor, and a hydrophilic phase with an enzyme that catalyzes peracetic acid generation, maintaining components separately until use to enhance stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If highly reactive whitening agents are used to reduce treatment time, then whitening efficacy is improved, but stability of the composition deteriorates
Solution Approach 1:
The composition is divided into two separate phases: a hydrophobic phase containing hydrogen peroxide and an acyl donor, and a hydrophilic phase containing the enzyme. This segmentation prevents premature reaction between components while maintaining stability during storage, and enables rapid peracetic acid generation when phases are mixed during use.
Solution Approach 2:
The enzyme acts as an intermediary catalyst that facilitates the reaction between hydrogen peroxide and acyl donor to generate peracetic acid. By using the enzyme as a mediator, the system achieves rapid generation of the active whitening agent without requiring direct contact between unstable reactants during storage.
2Loss of time
If multiple whitening agents are incorporated to oxidize different chromophores, then treatment time is reduced, but composition complexity increases
Solution Approach 1:
The system changes the chemical parameters dynamically by generating peracetic acid in situ from hydrogen peroxide and an acyl donor through enzyme catalysis. This parameter change approach allows the composition to maintain stability during storage while providing multiple oxidation mechanisms during treatment, effectively addressing different chromophores without requiring multiple pre-mixed agents.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition maintains high stability for at least 8 weeks under accelerated aging conditions, with sufficient peracetic acid generation for effective teeth whitening without encapsulation, reducing treatment time.
Implementation Method 1
an enzyme that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor
Implementation Method 2
an enzyme that catalyzes the generation of peracetic acid
Implementation Method 3
oral care conventional whitening gels including hydrogen peroxide are often utilized to oxidize chromophores bound to surfaces of teeth to thereby whiten the teeth
Data Source
AI summary
An oral care composition including a hydrophobic phase and a hydrophilic phase is disclosed. The hydrophobic phase may include a source of hydrogen peroxide and an acyl donor, and the hydrophilic phase may include an enzyme having perhydrolytic activity that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor.