Two-piece prosthetic valve with adjustable leaflets
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Solution Overview
Problem
Existing prosthetic valves are often sized and configured for specific valve types, requiring multiple productions and posing challenges in secure attachment to cardiovascular tissues, with high risks of perivalvular leakage and harsh biological responses.
Innovation Solution
Two-piece prosthetic valves with extracellular matrix material and anchoring mechanisms for secure attachment, capable of forming multiple leaflets and administering pharmacological agents to promote tissue regeneration and reduce intimal hyperplasia.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If one-piece prosthetic valves are produced for specific valve types, then valve replacement can be performed, but multiple different valve types must be produced and surgical complexity increases
Solution Approach 1:
The prosthetic valve is designed with a universal structure that can replace multiple types of native valves (aortic, pulmonary, mitral, tricuspid, and peripheral venous valves) through a single standardized device. The valve incorporates adjustable parameters including diameters of 15-80mm, lengths of 20-100mm, and configurable leaflet numbers (1-6) to adapt to different valve positions and requirements, eliminating the need for multiple specialized valve types.
Solution Approach 2:
The valve is constructed as a two-piece assembly with a first member and a second member that can be separately manufactured and then joined together. This segmentation allows for optimized manufacturing of each component and enables customization of the valve configuration (number of leaflets, diameters, lengths) while maintaining a standardized basic structure that reduces surgical complexity.
2Reliability
If conventional prosthetic valves are used, then valve replacement is achieved, but perivalvular leakage occurs and biological responses are harsh
Solution Approach 1:
The valve incorporates an anchoring mechanism with enhanced local properties at the attachment region. The anchoring structure includes features such as anchoring elements, reinforcing rings, or coated surfaces that provide localized enhancement to prevent perivalvular leakage and reduce harmful biological responses at the interface with host tissue, while maintaining the overall simplicity of the valve structure.
Solution Approach 2:
The valve is constructed using composite materials that combine different properties to achieve both structural integrity and biocompatibility. The valve may incorporate extracellular matrix materials, coatings, or composite structures that reduce perivalvular leakage and minimize harsh biological responses while maintaining mechanical strength and valve functionality.
3Adaptability or versatility
If multiple prosthetic valve types are manufactured, then specific valve replacements are possible, but production costs and inventory requirements increase
Solution Approach 1:
A single standardized prosthetic valve design can replace multiple native valve types through adjustable parameters. The valve can be configured with different diameters (15-80mm), lengths (20-100mm), and leaflet numbers (1-6) to suit various valve positions and requirements, eliminating the need to manufacture and inventory multiple specialized valve types.
Solution Approach 2:
The valve is divided into a first member and a second member that can be manufactured separately using standardized processes and then joined together. This segmentation enables flexible configuration of the valve (adjusting leaflet numbers, diameters, lengths) while maintaining a standardized basic structure that simplifies manufacturing and reduces production complexity.
Data Source
AI summary
A two-piece prosthetic valve having first and second members, a first end of the first member being sized and configured to receive a second end of the second member therein, the second end of the second member being attached to the first member at at least one commissure connection point to form at least one leaflet therein.