Two-Reactant Tissue Adhesive Sheet for Bloodborne Infection Risk
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Solution Overview
Problem
Conventional sheet-shaped tissue adhesives/reinforcements face challenges in safety and convenience due to the risk of blood-derived infectious diseases from fibrinogen formulations and the need for blood coagulation ability, as well as inadequate adhesiveness of aliphatic polymer-based materials, which require additional fibrinogen formulations for reinforcement.
Innovation Solution
A biodegradable sheet-shaped adhesive/reinforcement using a two-reactant adhesive powder fixed to a porous base, where the powder is dispersed in absolute ethanol and applied to a biodegradable porous sheet, allowing for secure attachment and maintaining reactivity and adhesiveness, enabling firm adherence to living tissues without relying on blood coagulation or fibrinogen.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fibrinogen formulations are used for tissue adhesion, then adhesion effectiveness is improved, but risk of blood-derived infectious diseases increases
Solution Approach 1:
The patent extracts and eliminates the harmful fibrinogen component from the tissue adhesive formulation, replacing it with a synthetic two-reactant adhesive system consisting of a polymer backbone and a crosslinking agent that does not rely on blood components, thereby maintaining adhesion effectiveness while removing the risk of blood-derived infections
Solution Approach 2:
The patent employs a biodegradable porous base sheet made of aliphatic polymer that can be safely discarded after serving its purpose, combined with a temporary adhesive layer that degrades over time, eliminating the need for permanent implants and reducing long-term safety concerns
2Object-affected harmful factors
If aliphatic polymer-based materials are used for tissue reinforcement, then safety is improved, but adhesiveness to biological tissue deteriorates
Solution Approach 1:
The patent creates a composite structure combining an aliphatic polymer base sheet with a two-reactant adhesive coating, where the adhesive layer comprises a polymer backbone and crosslinking agent that chemically bonds to both the base sheet and biological tissue, achieving both safety of the polymer and adhesiveness of the reactive adhesive system
Solution Approach 2:
The patent modifies the surface properties of the aliphatic polymer base sheet through controlled porosity and surface treatment, creating a porous structure that enhances mechanical interlocking with tissue while maintaining the chemical inertness and safety of the polymer material
3Reliability
If conventional sheet-shaped tissue adhesives are used, then tissue reinforcement is achieved, but handleability and convenience deteriorate
Solution Approach 1:
The patent uses a flexible aliphatic polymer base sheet with controlled thickness and porosity that can be easily manipulated and conform to irregular tissue surfaces, while the integrated adhesive coating provides sufficient bond strength without requiring complex application procedures or additional components
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a safe, convenient, and effective tissue reinforcement that adheres to living tissues, prevents liquid and gas leakage, and promotes hemostasis, while eliminating the risk of infection and improving handleability.
Implementation Method 1
a two-reactant adhesive powder which is capable of reacting with water to be converted into a hydrogel state
Implementation Method 2
the powder is dispersed in absolute ethanol and applied to a biodegradable porous sheet
Implementation Method 3
the powder is dispersed in absolute ethanol and applied to a biodegradable porous sheet
Implementation Method 4
a biodegradable sheet-shaped adhesive/reinforcement using a two-reactant adhesive powder fixed to a porous base
Data Source
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AI summary
A sheet-shaped tissue adhesive/reinforcement and its producing method in a manner as below, which realizes a good tissue reinforcing effect and handleability without the need to utilize fibrinogen and the blood coagulation ability derived from the patient being applied. The sheet-shaped tissue adhesive reinforcement comprises a base sheet having a biodegradability and communicative porous structure, and an adhesive resin layer fixed and formed on the base sheet. This adhesive resin layer comprises a first reactant comprising an aldehyded glycan and a second reactant comprising partially carboxylated polylysine, and has a granular structure derived from the powder of the first reactant and a connecting layer, which is derived from the second reactant and connects the granular structures to each other and fixes them to the base sheet. In a way to produce such reinforcement, a mixed powder of the first and second reactant is used. For example, this mixed powder is dispersed in ethanol having a water content of less than 1%, and the dispersion is applied onto the base sheet and then dried.