Ultrasound Contrast Agent Activation Device with Auto-Identification
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Solution Overview
Problem
Existing ultrasound contrast agents (UCAs) require proper activation to ensure appropriate size and concentration of gas-filled microspheres, but human error in activation can lead to suboptimal or unsafe UCA preparations.
Innovation Solution
A method and device for identifying and distinguishing between different UCA formulations, such as DEFINITY and DEFINITY-II, and automatically activating them for specific pre-determined periods of time using a shaking device with a detector capable of reading unique identifiers on the UCA containers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual activation of UCA formulations is performed, then flexibility in handling different formulations is maintained, but human error increases leading to incorrect activation parameters
Solution Approach 1:
The system enables self-service activation by allowing the UCA formulation container to automatically identify itself through unique identifiers (barcodes, RFID tags, or physical characteristics). The activation device reads these identifiers and autonomously determines the correct activation parameters without requiring manual intervention or user knowledge of the specific formulation type.
Solution Approach 2:
The activation device incorporates feedback mechanisms by reading identification information from the UCA container and using this information to automatically adjust activation parameters. The system receives feedback from the identifier recognition system and dynamically configures the activation process accordingly, ensuring the correct parameters are applied for each specific formulation.
2Adaptability or versatility
If multiple UCA formulations with different activation parameters are used, then diagnostic capabilities are enhanced, but the risk of applying incorrect activation parameters increases
Solution Approach 1:
The system introduces an intermediary identification layer between the diverse UCA formulations and the activation device. Unique identifiers (barcodes, RFID tags, or physical container characteristics) serve as mediators that translate the variety of formulations into a standardized recognition system, allowing the activation device to correctly handle different formulations without requiring complex manual configuration.
Solution Approach 2:
The activation device is designed with universal functionality to handle multiple UCA formulations through a single interface. By incorporating multiple identification methods (barcode scanning, RFID reading, physical characteristic detection), the device can universally recognize and appropriately activate any UCA formulation type without requiring separate specialized equipment for each formulation.
3Reliability
If automated identification and activation systems are implemented, then human error is reduced, but device complexity and cost increase
Solution Approach 1:
The system uses copies or representations of identification information (barcodes, RFID tags, or physical characteristic patterns) stored on or associated with the UCA container. Instead of requiring complex analysis of the actual formulation contents, the device reads these simplified copies/representations to determine activation parameters, significantly reducing system complexity while maintaining high reliability.
Solution Approach 2:
The system replaces manual mechanical operations (visual inspection, manual parameter selection, physical adjustment) with automated detection and control mechanisms. Barcode scanners, RFID readers, or optical sensors automatically identify the formulation, and computer control systems automatically configure activation parameters, eliminating human error while keeping the added complexity manageable through standardized interfaces.
Data Source
AI summary
Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA suitable for in vivo use.