UHT Nutritional Composition Stability

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Solution Overview

Problem

Current high-calorie liquid nutritional compositions with energy densities of 2.0 kcal/ml or more are typically sweet in taste and prone to coagulation or precipitation during UHT treatment, making it difficult to achieve a savory taste while meeting regulatory sodium and potassium chloride concentrations, which are essential for nutritional completeness.

Innovation Solution

A nutritional composition with a caloric content of 1.8-2.8 kcal/ml, comprising 9-14 g/100 ml of protein, at least 90 wt.% maltodextrins with a dextrose equivalent of 15-18, and a balanced electrolyte system, including sodium and potassium salts, that remains liquid after UHT treatment and has a savory taste without being overly sweet, achieved by optimizing the protein, carbohydrate, and mineral content.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Use of energy by moving object

If the caloric content of the nutritional composition is increased to meet high energy needs (2.0 kcal/ml or more), then the energy density is improved, but the composition becomes prone to coagulation and precipitation during UHT treatment

Engineering Contradiction:
Improvecaloric contentVSAvoidstability during UHT treatment
Core Design Contradiction:
Use of energy by moving objectVSReliability

Solution Approach 1:

The patent changes the chemical composition parameters by specifying a protein content of 9-14 g/100 ml and using maltodextrins with a specific dextrose equivalent of 15-18, which alters the physical-chemical properties of the composition to prevent coagulation during UHT treatment while maintaining high caloric content

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite nutritional composition combining specific proportions of protein (9-14 g/100 ml), maltodextrins (at least 90 wt.% with DE 15-18), fat, and balanced electrolytes, where the interaction between these components provides both high caloric density and stability during UHT treatment

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If sodium and potassium chloride concentrations are increased to meet regulatory guidelines for nutritional completeness, then the nutritional value is improved, but coagulation and precipitation occur during UHT treatment

Engineering Contradiction:
Improvesalt concentrationVSAvoidstability during UHT treatment
Core Design Contradiction:
Quantity of substanceVSReliability

Solution Approach 1:

The patent adjusts the electrolyte composition parameters by specifying a balanced electrolyte system with controlled sodium and potassium salt concentrations that meet regulatory requirements while preventing coagulation, achieved through the specific protein and carbohydrate matrix

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The maltodextrins with dextrose equivalent of 15-18 act as an intermediary substance that stabilizes the interaction between proteins and electrolytes during UHT treatment, preventing coagulation while allowing sufficient salt concentrations for nutritional completeness

Inventive Principle:
Principle #24Intermediary (Mediator)

3Use of energy by moving object

If the proportion of all nutritional components is increased to achieve high caloric content, then the energy density is improved, but the viscosity increases making the composition too thick to pass through UHT lines

Engineering Contradiction:
Improvecaloric contentVSAvoidflowability through UHT line
Core Design Contradiction:
Use of energy by moving objectVSEase of manufacture

Solution Approach 1:

The patent optimizes the molecular structure parameters by selecting maltodextrins with a specific dextrose equivalent of 15-18, which have appropriate chain lengths that provide caloric density without excessive viscosity, enabling the composition to flow through UHT lines

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent applies different functional roles to different components: proteins (9-14 g/100 ml) provide structural stability, maltodextrins provide caloric content with controlled viscosity, and electrolytes provide nutritional completeness, with each component optimized for its specific function

Inventive Principle:
Principle #3Local quality

Data Source

PatentEP3298907B2High calorie, UHT treated liquid nutritional compositions
Publication Date: 2022.10.19 FRESENIUS KABI DEUTSCHLAND GMBH
  • EP3298907B2 patent drawingFigure 1~2

AI summary

UHT treated liquid nutritional compositions are provided having a high caloric content of around 2.0 kcal/ml and higher, a savoury taste and comprising protein, carbohydrate and fat components. The nutritional compositions are for use in the treatment of patients having high energy needs.