Ulmi Cortex Extract Inhibits Apoptosis via PI3K/Akt Pathway

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Solution Overview

Problem

Current therapeutic methods are inadequate for effectively preventing and treating ovarian aging and premature ovarian failure, which can lead to reduced fertility and early menopause, due to the toxic effects of harmful factors on ovarian tissues and germ cells.

Innovation Solution

Administration of an Ulmi cortex extract, obtained from the bark of Ulmus macrocarpa Hance, which is processed into a pharmaceutical or food composition, to inhibit ovotoxicity and protect ovarian cells from damage, thereby preventing or treating ovarian aging and premature ovarian failure.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional therapeutic methods are used for preventing and treating ovarian aging, then general body aging can be addressed, but ovarian-specific aging and premature ovarian failure cannot be adequately treated

Engineering Contradiction:

Improvetreatment effectiveness for ovarian agingVSAvoidspecificity to ovarian tissue

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent segments the therapeutic approach by specifically targeting ovarian tissue with Ulmi cortex extract, separating ovarian aging treatment from general body aging treatment. This allows the composition to address ovarian-specific cellular mechanisms while maintaining overall health benefits.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Ulmi cortex extract acts as an intermediary substance that mediates protection between ovarian cells and ovotoxic factors. The extract contains specific compounds that intervene in the toxic pathway, preventing direct damage to ovarian tissues while being administered systemically.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If ovarian aging is treated only by addressing general body aging, then overall health can be maintained, but fertility preservation and prevention of premature ovarian failure are insufficient

Engineering Contradiction:

Improvefertility preservationVSAvoidtreatment complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The Ulmi cortex extract composition performs multiple functions simultaneously: it protects against general aging, prevents ovotoxicity, preserves fertility, and treats premature ovarian failure. This multi-functional approach simplifies the treatment regimen while addressing multiple ovarian health concerns.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent emphasizes preliminary protection against ovotoxicity before irreversible ovarian damage occurs. By administering the extract proactively to prevent cellular damage, the treatment preserves fertility and prevents premature ovarian failure before clinical symptoms manifest.

Inventive Principle:

Principle #10Preliminary action

3Reliability

If high concentrations of Ulmi cortex extract are used to maximize protective effects, then ovotoxicity inhibition is improved, but potential side effects and toxicity may increase

Engineering Contradiction:

Improveovotoxicity protectionVSAvoidpotential extract toxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes the concentration parameters of Ulmi cortex extract in the composition to achieve maximum protective effect while minimizing potential toxicity. By carefully controlling the extract concentration and formulation parameters, the composition achieves therapeutic efficacy with an improved safety profile.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The Ulmi cortex extract demonstrates protective effects against ovotoxicity by inhibiting apoptosis and activating the PI3K/Akt signaling pathway, effectively preventing or alleviating ovarian aging and premature ovarian failure, as shown by its antioxidant activity and cell viability preservation in preclinical studies.

Implementation Method 1

The Ulmi cortex extract demonstrates protective effects against ovotoxicity by inhibiting apoptosis and activating the PI3K/Akt signaling pathway

Methodology Applied

Scientific EffectPI3K/Akt signaling pathway activation:

Implementation Method 2

as shown by its antioxidant activity and cell viability preservation in preclinical studies

Methodology Applied

Scientific EffectAntioxidant activity:

Data Source

PatentUS10434128B2Composition comprising Ulmi cortex extracts for inhibiting ovotoxicity

Publication Date: 2019.10.08 DONGGUK UNIV GYEONGJU CAMPUS IND ACAD COOPERATION FOUND

AI summary

Provided is a method of treating ovotoxicity of an individual, including administering an Ulmi cortex extract to an individual in need of treatment. The present disclosure may exhibit an effect of preventing, alleviating, or treating ovarian aging or premature ovarian failure by inhibiting oxidative stress or ovotoxicity of the ovaries.