Ultrasound Therapy System with Microbubble Resonance for Precise Dose Control
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Solution Overview
Problem
Current ultrasound therapy systems for cancer treatment, particularly HIFU and LIFU+MB, face challenges in accurately determining effective ultrasound irradiation doses for cell and animal experiments, leading to inefficiencies and potential harm due to the need for repeated animal dissection and external factor interference.
Innovation Solution
An ultrasound therapy system comprising a control device, multiple ultrasound irradiation devices, and a characterization image capture device to generate and adjust ultrasound doses based on performance characteristic data, ensuring precise targeting of abnormal proliferation cells or organisms with microbubble assistance, minimizing tissue damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high-intensity focused ultrasound (HIFU) is used to achieve sufficient therapeutic effect, then tumor treatment efficacy is improved, but safety deteriorates due to burns of adjacent organs caused by acoustic wave offset or scattering
Solution Approach 1:
The patent transitions from high-intensity focused ultrasound (HIFU) to low-intensity focused ultrasound (LIFU) by changing the intensity parameter. This allows the use of microbubbles as contrast agents that resonate at specific frequencies, amplifying local energy at the tumor site while reducing overall ultrasound intensity to avoid damaging adjacent organs.
Solution Approach 2:
The patent introduces microbubbles as an intermediary substance that mediates the ultrasound-tissue interaction. The microbubbles resonate with low-intensity ultrasound waves, concentrating energy at the tumor site through resonance amplification, thereby achieving therapeutic effects without requiring high-intensity ultrasound that would cause collateral damage.
2Object-affected harmful factors
If low-intensity focused ultrasound (LIFU) combined with microbubbles is used to improve safety, then safety is improved, but device complexity increases due to the need for additional microbubble injection systems and characterization devices
Solution Approach 1:
The patent designs the ultrasound irradiation device to perform multiple functions: it can irradiate both cell culture devices and living organisms, and the same device can be used for both LIFU and HIFU modes. The control device manages multiple irradiation devices and coordinates microbubble injection, making the system versatile for different experimental needs without requiring separate specialized equipment for each function.
3Measurement precision
If repeated animal dissection is performed to observe ultrasound effects, then measurement precision is improved, but loss of time increases and productivity deteriorates
Solution Approach 1:
The patent replaces the mechanical dissection process with non-invasive imaging technology. The characterization image capture device uses imaging methods to observe and measure ultrasound effects in living organisms in real-time, eliminating the need for repeated surgical dissection while maintaining measurement accuracy and significantly improving experimental efficiency.
4Measurement precision
If multiple groups of animals are used for dose determination experiments, then measurement precision is improved, but quantity of substance increases leading to more animal dissection and ethical concerns
Solution Approach 1:
The patent makes the ultrasound irradiation device and characterization system universal, allowing the same device to be used for both cell culture experiments and living organism experiments. This enables researchers to first determine effective doses in cell cultures, then directly apply and verify those doses in living organisms using the same equipment, reducing the need for separate animal groups and minimizing animal usage while maintaining dose determination accuracy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient and safe determination of effective ultrasound doses for cancer treatment, reducing animal usage and experimental complexity while ensuring therapeutic efficacy and safety by characterizing cell and tissue responses to ultrasound irradiation.
Implementation Method 1
When irradiated by low-energy ultrasound, the gas nucleus of the MB undergoes resonance motion, and the local energy is amplified, resulting in a therapeutic effect.
Implementation Method 2
the gas nucleus of the MB undergoes resonance motion
Data Source
AI summary
The present disclosure provides an ultrasound therapy system and a dose control method. The system includes: a control device; a first ultrasound irradiation device configured to generate multiple groups of ultrasound irradiation doses driven by the control device and conduct ultrasound irradiation on a cell culture device with multiple groups of abnormally proliferating living cells; a characterization image capture device configured to capture performance characteristic data of living cells in the cell culture device, where the control device is further configured to determine an ultrasound irradiation dose corresponding to at least one group of abnormally proliferating living cells with a cell target characteristic characterization as a target ultrasound irradiation dose according to the performance characteristic data; and a second ultrasound irradiation device configured to conduct ultrasound irradiation of the target ultrasound irradiation dose on a living organism with abnormal proliferation.