Ulva lactuca Extract Nrf2-ARE Pathway Activation
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Solution Overview
Problem
There is an unmet need for additional antioxidants and treatments for reactive oxygen species (ROS)-mediated diseases, such as inflammation, cancer, Alzheimer's disease, and other neurodegenerative disorders, as current therapies are insufficient in addressing these conditions effectively.
Innovation Solution
Seaweed extract compositions, specifically from the green alga Ulva lactuca, are isolated and processed to enrich active fractions and compounds that activate the Nrf2-ARE pathway, providing new therapeutic options for ROS-mediated diseases by modulating cytoprotective gene expression.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current antioxidant therapies are used, then treatment of ROS-mediated diseases is provided, but the treatment effectiveness is insufficient
Solution Approach 1:
The patent extracts and isolates specific active compounds (compounds 1, 2, and 3) from the seaweed Ulva lactuca through systematic extraction and purification processes. This extraction principle allows obtaining concentrated active ingredients with proven Nrf2-ARE pathway activation capability, thereby improving treatment effectiveness while providing specific therapeutic options for ROS-mediated diseases
Solution Approach 2:
The patent identifies and utilizes the Nrf2-ARE pathway as a molecular intermediary mechanism. The isolated compounds from Ulva lactuca act as mediators that activate this specific signaling pathway, which in turn induces cytoprotective enzymes and antioxidant defenses. This intermediary approach provides a targeted mechanism for improving treatment effectiveness against ROS-mediated diseases
2Adaptability or versatility
If seaweed extract compositions are isolated and processed to enrich active fractions, then new therapeutic options are provided, but the process complexity increases
Solution Approach 1:
The patent segments the complex seaweed extract into distinct active fractions and isolated compounds (compounds 1, 2, and 3) through systematic extraction and purification steps. This segmentation approach breaks down the complex isolation process into manageable stages, enabling the enrichment of specific active components while providing multiple therapeutic options with defined chemical structures and activities
Solution Approach 2:
The patent employs parameter changes in the extraction and purification processes, including solvent selection, temperature control, and concentration adjustments, to optimize the enrichment of active fractions from Ulva lactuca. These parameter optimizations enable effective isolation of therapeutic compounds while managing the complexity of the processing workflow
Data Source
AI summary
The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.