Umbilical Cord Blood Processing System with Centrifuge Housing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for processing umbilical cord blood samples face challenges such as bag damage and blood spillage during centrifugation, leading to loss of valuable components and potential infectious risks. Additionally, manual isolation of blood components is imprecise and requires significant operator judgment, affecting the quality of the final product. Furthermore, temperature control during cryoprotectant administration is unpredictable, compromising sample preservation.
Innovation Solution
A comprehensive blood processing system comprising a blood bag housing device, an isolation device, and a cryopreparation device. The blood bag housing device securely positions the blood bag during centrifugation, minimizing the risk of damage. The isolation device facilitates precise manual or automated isolation of blood components, reducing operator judgment and improving product quality. The cryopreparation device ensures consistent temperature control during cryoprotectant administration, maintaining optimal conditions for sample preservation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If centrifugation is performed to separate blood components, then blood component separation is achieved, but bag damage and blood spillage occur due to high centrifugal force
Solution Approach 1:
A cushioning material is placed at the bottom of the centrifuge bucket before inserting the blood bag. This cushioning layer absorbs and distributes the centrifugal force, preventing direct impact on the blood bag and avoiding bag damage or blood spillage during high-speed centrifugation.
2Ease of operation
If manual isolation of blood components is performed, then operator flexibility is maintained, but isolation precision is compromised due to reliance on operator judgment
Solution Approach 1:
An automated isolation device with optical sensors and automated control systems replaces manual visual inspection and judgment. The system automatically identifies blood component boundaries and performs precise isolation, eliminating reliance on operator judgment while maintaining operational flexibility through programmable control.
3Temperature
If traditional ice storage is used during cryoprotectant administration, then cooling is provided, but temperature control is unpredictable leading to sample compromise
Solution Approach 1:
A temperature control system with sensors and feedback control is implemented during cryoprotectant administration. The system continuously monitors temperature and adjusts cooling parameters in real-time to maintain precise temperature control, eliminating the unpredictable temperature spikes associated with traditional ice storage methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively prevents bag damage and blood spillage during centrifugation, ensuring the integrity and availability of blood components. It enhances the precision and efficiency of blood component isolation, improving the quality of the final product. Additionally, it maintains precise temperature control, ensuring the optimal preservation of samples for cryostorage.
Implementation Method 1
Centrifugation is a necessary process for the separation of blood components or, more specifically, umbilical cord blood components including plasma, red blood cells, and white blood cell concentrates
Data Source
AI summary
A blood sample processing system and method for processing of umbilical cord blood is disclosed. The processing system is configured to ensure reliable processing of the blood sample from collection to testing, and includes a blood bag housing device, an isolation device, and a cryopreparation device. The blood bag housing device provides a secure and reliable housing for a blood sample bag while in the bucket of a centrifuge. The isolation device provides a simple and repeatable system for the isolation of the blood components separated during centrifugation. The isolated blood component sample from the isolation device is transferred into a cryobag and is ready for the administration of the cryoprotectant. The cryopreparation device provides a system with controlled temperature, ensuring precise conditions for the administration of cryoprotectant to the isolated blood component sample from the isolation device.