Umbilical Cord Mesenchymal Cell Bone Regeneration Composition

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Solution Overview

Problem

Current methods for bone tissue regeneration, such as autologous bone grafts, often fail to fully replace damaged tissue, are associated with surgical risks, and lack the regenerative activity of cellular components, making them inadequate for all patients, especially recurrent cases.

Innovation Solution

A composition combining mesenchymal cells with osteogenic potential derived from Wharton's jelly of the umbilical cord, deantigenised bone particles, and a fibrinogen hydrogel, which adapts to the shape of bone defects, providing structural support and promoting vascularization and osteoinduction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If autologous bone grafts are used for bone tissue regeneration, then structural support and growth factors are provided, but surgical risks and morbidity increase

Engineering Contradiction:

Improvebone regeneration effectivenessVSAvoidsurgical risks and morbidity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The invention extracts the beneficial components (mesenchymal cells, growth factors) from autologous bone tissue and combines them with allogeneic bone particles, separating the regenerative function from the surgical harvesting procedure, thereby eliminating morbidity while maintaining regeneration effectiveness

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention creates a composite bone graft composition combining autologous mesenchymal cells with allogeneic bone particles, merging the regenerative advantages of cellular components with the structural support of bone material, achieving both effectiveness and safety

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If bony particles from tissue banks are used, then surgical risks are reduced, but regenerative activity is lost

Engineering Contradiction:

Improvesurgical risksVSAvoidregenerative activity

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The invention merges allogeneic bone particles (providing structural support and safety) with autologous mesenchymal cells (providing regenerative activity), creating a composite that delivers both benefits simultaneously

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Inventive Principle:

Principle #40Composite materials

3Reliability

If complete substitution of damaged bone tissue is achieved, then long-term success is improved, but the complexity of treatment increases

Engineering Contradiction:

Improvelong-term successVSAvoidtreatment complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The invention employs the patient's own mesenchymal cells that automatically differentiate and regenerate bone tissue at the defect site, allowing the body's natural regenerative mechanisms to complete the substitution process without requiring complex multi-stage interventions

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively regenerates bone tissue by maintaining cellular viability and osteogenic potential, adapting to defect morphology, and ensuring nutrient supply, reducing surgical risks and improving regeneration outcomes.

Implementation Method 1

a hydrogel of fibrinogen... adapting its shape to the tridimensional architecture of the fracture site or bony defect

Methodology Applied

Scientific EffectHydrogel: Hydrogel

Implementation Method 2

contributes with growth factors that promote vascularisation and osteoinduction

Methodology Applied

Scientific EffectOsteoinduction:

Implementation Method 3

mesenchymal cells with osteogenic potential... induce the regeneration of damaged bony tissue

Methodology Applied

Scientific EffectCell differentiation:

Implementation Method 4

bony particles hold the capacity of osteoinduction and osteoconduction

Methodology Applied

Scientific EffectOsteoconduction:

Implementation Method 5

produce a biological environment that ensures the supply of nutrients to the cells

Methodology Applied

Scientific EffectDiffusion: Diffusion

Data Source

PatentEP3456363B1Composition for regenerating bony tissue, method for preparation and use thereof

Publication Date: 2020.11.04 BANC DE SANG I TEIXITS

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AI summary

The present invention discloses a composition for regenerating bony tissue, comprised of one or more mesenchymal cells from the umbilical cord with osteogenic potential, bony particles and a hydrogel of fibrinogen. The present invention also refers to a method of preparation and use of said composition.