Uniform Microtablets for Reliable Individual Dosing
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Solution Overview
Problem
Conventional microtablets for pharmaceutical administration are difficult to dose individually due to separation issues when mixed, making reliable dosing challenging for patients, especially when using hard gelatin capsules that are hard to swallow or divide.
Innovation Solution
A pharmaceutical preparation comprising microtablets with the same spatial shape and weight, ensuring uniform density and distribution, allowing for easy combination and dosing without separation, facilitating individualized administration without the need for capsules.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If microtablets with different constituents are mixed for individual dosing, then dosing flexibility is improved, but separation and uniform distribution become problematic
Solution Approach 1:
The patent changes the physical parameter of density by making all microtablets have the same density regardless of their constituent composition. This parameter uniformity ensures that microtablets with different active compounds mix uniformly and can be dosed individually without separation, resolving the contradiction between dosing flexibility and uniform distribution.
2Strength
If hard gelatin capsules are used for microtablet administration, then containment is improved, but ease of swallowing and patient convenience deteriorate
Solution Approach 1:
The patent extracts and removes the hard gelatin capsule from the administration system entirely. Instead of using capsules to contain microtablets, the invention allows direct administration of the microtablets themselves, eliminating the swallowing difficulty associated with hard gelatin capsules while maintaining effective containment through the microtablet formulation itself.
3Measurement precision
If capsule contents are divided for individual dosing, then dosing precision is improved, but effort and complexity increase significantly
Solution Approach 1:
The patent segments the dosing process at the microtablet level itself, where each microtablet is a pre-measured unit with precise active compound content. This eliminates the need for patients to divide capsule contents, as the segmentation is already built into the microtablet formulation, thereby maintaining dosing precision while significantly reducing dosing complexity.
Data Source
AI summary
A pharmaceutical preparation consisting of various microtablets containing ingredients. The microtablets have the same form and the same weight.