Uniform Pathogen Reduction in Biological Fluids via Dynamic Radiation Control
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Solution Overview
Problem
Existing methods for treating biological samples with electromagnetic radiation to reduce pathogens often result in nonuniform treatment due to variations in sample volume and mass, leading to inconsistent pathogen reduction and potential damage to therapeutic agents.
Innovation Solution
The development of methods and devices that uniformly deliver electromagnetic radiation to fluid samples by adjusting net radiant energy and mixing rates based on sample volume, mass, and mixing characteristics, ensuring all particles receive equivalent effective net radiant energies for uniform pathogen reduction and maintaining biological activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If electromagnetic radiation is applied to treat pathogens in biological samples, then pathogen reduction is achieved, but treatment uniformity deteriorates due to variations in sample volume and mass
Solution Approach 1:
The patent adjusts net radiant energy parameters based on sample volume and mass variations. By dynamically changing the radiation dosage parameters to match sample characteristics, the system achieves uniform pathogen reduction across different sample sizes while maintaining treatment consistency
Solution Approach 2:
The system incorporates feedback mechanisms that monitor treatment parameters and adjust radiation delivery in real-time. This feedback control ensures that variations in sample volume and mass are compensated, maintaining both pathogen reduction effectiveness and treatment uniformity
2Productivity
If higher electromagnetic radiation intensity is used to improve pathogen reduction efficiency, then pathogen reduction speed increases, but damage to therapeutic agents worsens
Solution Approach 1:
The patent applies different radiation intensities to different regions or aspects of the treatment process. By optimizing radiation parameters locally for pathogen targets while protecting therapeutic agents through selective exposure or shielding, the system achieves high pathogen reduction efficiency without compromising agent integrity
Solution Approach 2:
The system dynamically adjusts radiation intensity during the treatment process. By modulating the radiation dose in real-time based on treatment progress and sample response, the system maximizes pathogen destruction while minimizing damage to therapeutic components
3Reliability
If net radiant energy is increased to ensure adequate pathogen reduction, then pathogen reduction effectiveness improves, but biological activity of therapeutic agents deteriorates
Solution Approach 1:
The patent optimizes net radiant energy parameters by adjusting wavelength, intensity, and exposure duration based on the specific biological sample characteristics. This parameter optimization ensures sufficient pathogen reduction while preserving the biological activity and composition stability of therapeutic agents
Solution Approach 2:
The system applies radiation doses that are sufficient for pathogen reduction but controlled to avoid excessive exposure. By carefully calibrating the radiation parameters to the minimum effective dose for pathogen elimination, the system maintains therapeutic agent biological activity while achieving reliable pathogen reduction
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach ensures consistent pathogen reduction across varying sample sizes, maintaining the biological integrity and therapeutic effectiveness of treated samples, thereby enhancing the safety and quality of biological fluids for re-infusion and therapeutic use.
Implementation Method 1
In photoinduced chemical reduction methods, effective amounts of one or more photosensitizers are added to a biological fluid, which may be subsequently mixed and illuminated with electromagnetic radiation. Illumination activates the photosensitizers, thereby initiating chemical reactions and/or physical processes which kill the pathogens present in the sample or substantially prevent pathogens from replicating.
Implementation Method 2
In direct photoreduction methods, illumination with electromagnetic radiation having selected wavelengths directly results in pathogen reduction.
Data Source
AI summary
Methods, devices and device components are presented for uniformly treating fluids undergoing mixing with electromagnetic radiation. In one aspect, the present invention provides methods of treating a fluid undergoing continuous fluid mixing wherein net radiant energies necessary to provide uniform treatment of the fluid samples with electromagnetic radiation are calculate on the basis of the volume, mass or mixing rate of the fluid or any combination of these variables. In another aspect, the present invention provides algorithms for determining net radiation energies, radiant powers, and/or illumination times necessary for providing uniform treatment of fluid samples. The present invention provides methods for uniformly reducing pathogens in biological fluids, including blood and blood components.