Uracil Compound Crystallization via Solvent Mixture
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Solution Overview
Problem
Existing methods for producing uracil compounds on an industrial scale struggle to achieve high purity, which is crucial for effective herbicide performance.
Innovation Solution
A method involving the dissolution of a crude uracil composition in a mixture of C3-C6 alcohol solvents and aromatic solvents, followed by crystallization, to produce high-purity crystals of the uracil compound.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a multistep reaction process is used to produce uracil compound on industrial scale, then productivity is improved, but manufacturing precision deteriorates
Solution Approach 1:
The patent applies parameter changes by optimizing the solvent composition ratio (alcohol solvent to aromatic solvent between 3:7 to 7:3), temperature parameters (cooling to 0-25°C), and pH parameters (adjusting to 2-4 with hydrochloric acid) to achieve high purity crystallization from crude reaction mixtures, thereby resolving the contradiction between industrial scale production and manufacturing precision
Solution Approach 2:
The patent extracts the target uracil compound from the crude reaction mixture through selective crystallization. By adding aromatic solvents to the alcohol solution and cooling, the uracil compound is selectively extracted as crystals, separating it from impurities and achieving high purity (95% or more) while maintaining industrial scale production
2Ease of manufacture
If conventional purification methods are used, then ease of manufacture is maintained, but manufacturing precision deteriorates
Solution Approach 1:
The patent utilizes phase transitions through controlled crystallization. By dissolving the crude uracil compound in hot alcohol solvent and then cooling the solution, the compound undergoes phase transition from dissolved state to crystalline state, achieving high purity separation through this physical phase change while maintaining process simplicity
Solution Approach 2:
The patent changes physical parameters including temperature (heating to dissolve, cooling to crystallize), solvent composition (adding aromatic solvent to alcohol solution), and pH (adjusting to 2-4) to control the crystallization process, achieving high purity while keeping the manufacturing process simple and scalable
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method effectively achieves high-purity crystals of the uracil compound, enhancing the herbicide's efficacy and ensuring compliance with industrial-scale production requirements.
Implementation Method 1
dissolving a crude uracil composition in organic solvents consisting of a C3-C6 alcohol solvent and an aromatic solvent to obtain a solution
Implementation Method 2
precipitating a crystal of the present uracil compound from the solution
Implementation Method 3
the crystal of the present uracil compound is precipitated by cooling a solution of a crude uracil composition
Data Source
AI summary
The invention provides a method for producing a crystal of a uracil compound with high purity by a process which can be carried out in an industrial scale. Specifically, the invention provides a method for producing a crystal of a uracil compound, wherein the method involves dissolving a composition containing a uracil compound represented by formula (1)in organic solvents consisting of a C3-C6 alcohol solvent and an aromatic solvent to obtain a solution, and precipitating a crystal of said uracil compound from the solution.