Urethral Stricture Treatment Membrane Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current minimally invasive treatments for urethral stricture do not effectively promote long-term epithelial function at the treatment site, limiting their effectiveness.
Innovation Solution
A trans-urethral urethroplasty method involving a treatment device with a delivery member and a treatment membrane, where the membrane is delivered to the urethral stricture area, secured by an expandable member, and allowed to graft, promoting epithelial function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If minimally invasive procedures (dilation, stent implantation, urethrotomy) are used to treat urethral stricture, then the invasiveness is reduced and patient recovery is faster, but the long-term effectiveness is limited because they do not promote epithelial function at the treatment site
Solution Approach 1:
The patent introduces a treatment membrane as an intermediary substance that is delivered to the treatment site via a delivery device. This membrane serves as a scaffold that promotes epithelial cell migration and regeneration, thereby enhancing long-term effectiveness while maintaining the minimally invasive nature of the procedure. The membrane acts as a mediator between the mechanical opening of the stricture and the biological healing process.
Solution Approach 2:
The patent changes the physical and chemical parameters of the treatment site by introducing a biocompatible membrane with specific properties (porosity, composition, degradation rate) that facilitate epithelial regeneration. The membrane's parameters are designed to match the physiological environment, promoting cell growth while maintaining structural integrity during the healing process.
2Reliability
If urethroplasty surgery is performed to treat extreme cases of urethral stricture, then long-term effectiveness and epithelial function are improved, but the invasiveness increases significantly
Solution Approach 1:
The treatment membrane serves as an intermediary that bridges the gap between minimally invasive procedures and traditional urethroplasty. It provides the biological benefits of tissue regeneration and epithelial promotion without requiring the extensive surgical intervention of traditional urethroplasty, thereby achieving similar long-term effectiveness with reduced invasiveness.
Solution Approach 2:
The patent employs a thin film membrane structure that can be delivered through a catheter-based delivery device. This flexible film conforms to the treatment site and provides the necessary biological support for epithelial regeneration, achieving the therapeutic effects of urethroplasty through a minimally invasive film-based approach rather than rigid surgical reconstruction.
3Reliability
If a treatment membrane is delivered to the treatment area using an expandable delivery member, then the membrane can be securely positioned and grafted to the treatment site, but the device complexity increases
Solution Approach 1:
The delivery device employs an expandable member that transitions from a compressed delivery state to an expanded deployment state. This dynamic transformation allows the device to navigate through the urethra in a compact form and then expand at the treatment site to securely position and deploy the membrane, achieving reliable positioning without requiring a permanently complex device structure.
Solution Approach 2:
The treatment membrane is nested within the expandable delivery member during delivery. The membrane is contained within the compressed structure of the delivery device, allowing it to be transported through the urethra in a compact form. Upon expansion, the membrane is deployed from the nested configuration to the treatment site, simplifying the overall device architecture while ensuring secure positioning.
Data Source
Figure 1
Figure 2a~2b
Figure 3a~3c
AI summary
A therapeutic device for treating a treatment area of a body lumen includes a delivery member possessing at least one attachment part, and a treatment membrane wrapped on the delivery member and detachably attached to the at least one attachment part of the delivery member