Uric Acid Neuroprotection in Mechanical Thrombectomy Stroke Treatment
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Solution Overview
Problem
Current treatments for brain stroke, particularly in patients treated with mechanical thrombectomy, lack effective therapies to improve survival rates and reduce brain damage, leading to a need for new or combined therapies that enhance functional independence and minimize brain injury.
Innovation Solution
Administration of uric acid, either alone or in combination with thrombolytic agents like tPA or citicoline, before, during, or after mechanical thrombectomy, to exploit its synergistic neuroprotective effects and mitigate oxidative stress and mitochondrial dysfunction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If mechanical thrombectomy is used to treat brain stroke, then blood flow is restored and clot is removed, but brain damage and functional independence remain poor outcomes
Solution Approach 1:
Uric acid acts as an intermediary neuroprotective agent between the mechanical thrombectomy procedure and the brain tissue. It mitigates oxidative stress and mitochondrial dysfunction that occur during and after the procedure, thereby reducing brain damage and improving survival rates without interfering with the mechanical clot removal process
Solution Approach 2:
The patent changes the biochemical parameters of the brain environment by administering uric acid, which alters oxidative stress levels, mitochondrial function, and cellular energy metabolism. This creates a more favorable biochemical environment that protects brain tissue from damage during the mechanical thrombectomy process
2Productivity
If standard stroke treatment protocols are used, then basic thrombolysis is provided, but functional independence and quality of life are not sufficiently improved
Solution Approach 1:
The patent merges mechanical thrombectomy with uric acid administration to create a combined treatment protocol. This combination synergistically improves functional independence and quality of life outcomes compared to standard thrombolysis alone, while maintaining treatment efficacy through the additive neuroprotective effects of uric acid
3Object-affected harmful factors
If uric acid is administered alone, then oxidative stress is reduced, but it cannot fully restore blood flow or remove clots
Solution Approach 1:
The treatment approach segments the stroke management process into two complementary components: mechanical thrombectomy for clot removal and blood flow restoration, and uric acid administration for oxidative stress reduction and neuroprotection. Each component addresses specific aspects of the pathology, and together they provide comprehensive treatment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Uric acid significantly improves outcomes for brain stroke patients by enhancing functional independence and reducing brain damage, demonstrating a synergistic effect when used in conjunction with mechanical thrombectomy, while maintaining safety and efficacy.
Implementation Method 1
Uric acid is a potent antioxidant which blocks the reaction between superoxide anion and nitric oxide, which damages the cells when nitrosylating thyroxine residues of proteins
Implementation Method 2
uric acid prevents the degradation of extra cellular superoxide dismutase, which is an essential enzyme for normal endothelial functioning
Implementation Method 3
Uric acid protects against excitotoxic damage by glutamate, stabilizing calcium homeostasis and preserving the mitochondrial function
Implementation Method 4
Uric acid has also shown the inhibition of the Fenton reaction
Data Source
AI summary
The present invention refers to a composition comprising uric acid for its use in the treatment of brain stroke in a patient treated by means of mechanical thrombectomy.