Urinary Stone Composition Using Citrate Salts and Plant Extracts

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Solution Overview

Problem

Current treatments for urinary tract stones focus primarily on mineral composition and formation, neglecting cellular mechanisms and the interaction between renal epithelial cells and calcium phosphate/calcium oxalate crystals, leading to incomplete prevention and management of stone formation and recurrence.

Innovation Solution

A composition comprising potassium citrate, magnesium citrate, phyllanthus extract, bromelain, rustyback extract, origanum extract, and Protium heptaphyllum extract, which synergistically works to inhibit calcium oxalate-induced cytotoxicity, reduce crystal aggregation, and promote the solubility of calcium oxalates in urine, thereby preventing and treating urinary tract stones.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current treatments focus primarily on mineral composition and formation, then the treatment approach is simple and well-established, but the prevention and management of stone formation and recurrence is incomplete

Engineering Contradiction:

Improveeffectiveness of stone prevention and managementVSAvoidcomplexity of treatment approach

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines multiple natural ingredients (phyllanthus extract, bromelain, nettle extract, rustyback extract, origanum extract, and Protium heptaphyllum extract) with citrate salts to create a composite composition that addresses both mineral composition and cellular mechanisms of stone formation, thereby improving effectiveness without requiring multiple separate treatments

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing various plant extracts and citrate salts that work synergistically to inhibit crystal aggregation, promote solubility of calcium oxalates, and provide anti-edema and anti-inflammatory effects, achieving comprehensive stone prevention and management

Inventive Principle:

Principle #40Composite materials

2Reliability

If only mineral composition is considered in stone treatment, then the treatment is straightforward, but cellular mechanisms and crystal-cell interaction are neglected leading to incomplete prevention

Engineering Contradiction:

Improvecompleteness of preventionVSAvoidcomplexity of mechanism coverage

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The composition performs multiple functions simultaneously: it inhibits calcium oxalate-induced cytotoxicity, reduces crystal aggregation, promotes solubility of calcium oxalates, and provides anti-edema and anti-inflammatory effects, thereby achieving complete prevention by addressing both mineral and cellular mechanisms

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent modifies the urinary environment by changing parameters such as citrate concentration, pH balance, and solubility characteristics through the action of citrate salts and plant extracts, thereby preventing stone formation at the cellular level while maintaining mineral balance

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces the formation and recurrence of urinary tract stones by inhibiting crystal aggregation, promoting the solubility of calcium oxalates, and providing anti-edema and anti-inflammatory effects, making it suitable for both prevention and treatment of acute stone symptoms.

Implementation Method 1

The composition comprises potassium citrate, magnesium citrate... promoting the solubility of calcium oxalates in urine

Methodology Applied

Scientific EffectComplexation:

Implementation Method 2

Stone formation occurs through supersaturation of minerals in the urine, which precipitate and form crystals

Methodology Applied

Scientific EffectSupersaturation: Supersaturation

Implementation Method 3

bromelain... which synergistically works to inhibit calcium oxalate-induced cytotoxicity, reduce crystal aggregation

Methodology Applied

Scientific EffectEnzyme action: Enzyme

Implementation Method 4

inhibiting crystal aggregation, promoting the solubility of calcium oxalates

Methodology Applied

Scientific EffectBiochemical inhibition:

Implementation Method 5

providing anti-edema and anti-inflammatory effects

Methodology Applied

Scientific EffectAnti-edema effect:

Implementation Method 6

providing anti-edema and anti-inflammatory effects

Methodology Applied

Scientific EffectAnti-inflammatory action:

Data Source

PatentEP4360640A1Composition for the treatment and prevention of urinary tract stones

Publication Date: 2024.05.01 ANVEST GRP SRL

Figure 1(a)~2(b)
Figure 3(a)~4(c)
Figure 5(a)~5(b)

AI summary

The invention relates to a composition comprising potassium citrate, magnesium citrate, a phyllanthus extract, bromelain, a nettle extract, a rustyback extract, an origanum extract and a Protium heptaphyllum extract. The composition of the invention, in the form of a medicament or dietary supplement, is useful in the treatment and prevention of urinary tract stones.