Urine Crystallization Analysis for Time-Specific Stone Risk

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Solution Overview

Problem

The 24-hour urine test for urinary calculi is inadequate in accurately reflecting high calculus-forming risks at specific periods, has complex and costly processing methods, and is inconvenient for long-term monitoring due to its reliance on multiple collections and complex interpretation of urine components.

Innovation Solution

A urine processing method that separates urinary sediment and supernatant for individual analysis, focusing on crystallization processes to assess urolithiasis risk, using crystallization and dry chemistry to analyze crystals in both phases, and a urine testing system to streamline this process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If 24-hour urine collection is used to assess calculus-related metabolites, then the concentration of metabolites can be accurately measured, but it cannot reflect the high calculus-forming risks at specific periods when urine concentration is high

Engineering Contradiction:

Improvemetabolite concentration measurementVSAvoidtemporal variation information

Core Design Contradiction:

Measurement precisionVSLoss of information

Solution Approach 1:

The patent divides the 24-hour urine collection into multiple time segments (morning, noon, evening collections) and analyzes each segment separately. This segmentation preserves temporal variation information while maintaining metabolite concentration measurement accuracy, allowing identification of high-risk periods for calculus formation.

Inventive Principle:

Principle #1Segmentation

2Measurement precision

If 24-hour urine test is used to detect calculus-related indicators, then metabolite concentrations can be assessed, but the interpretation is complex and urolithiasis risk assessment is inaccurate

Engineering Contradiction:

Improvemetabolite concentration detectionVSAvoidrisk assessment accuracy

Core Design Contradiction:

Measurement precisionVSLoss of information

Solution Approach 1:

The patent introduces a risk assessment model that serves as an intermediary between metabolite concentration data and clinical decision-making. This model integrates multiple metabolite concentrations with their respective weights to calculate a comprehensive urolithiasis risk score, simplifying interpretation while improving accuracy.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Adaptability or versatility

If 24-hour urine test with multiple analytes is performed, then comprehensive metabolic profile can be obtained, but the testing process becomes complex and costly

Engineering Contradiction:

Improvecomprehensive metabolite analysisVSAvoidtesting equipment and process

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent employs a multi-functional testing system that can detect multiple analytes (calcium, oxalate, uric acid, phosphate, magnesium, sodium, potassium, pH) using a unified platform. This universal approach maintains comprehensive metabolic profiling capability while reducing the need for multiple separate devices and simplifying the overall testing process.

Inventive Principle:

Principle #6Universality (Multi-functionality)

4Measurement precision

If 24-hour urine collection is required for calculus risk assessment, then metabolic indicators can be evaluated, but it is inconvenient for daily life and long-term monitoring

Engineering Contradiction:

Improvemetabolic indicator evaluationVSAvoidurine collection convenience

Core Design Contradiction:

Measurement precisionVSEase of operation

Solution Approach 1:

The patent divides the continuous 24-hour collection requirement into three separate, shorter collection periods (morning, noon, evening). Each segment can be collected independently without requiring continuous container carriage, significantly improving convenience for daily activities while maintaining the ability to assess temporal variations in metabolite concentrations.

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Provides direct and accurate urolithiasis etiology analysis and risk assessment, simplifies interpretation, reduces equipment and test costs, and facilitates convenient long-term monitoring.

Implementation Method 1

processing urine to obtain urinary sediment and supernatant

Methodology Applied

Scientific EffectCentrifugation: Centrifugal Separation

Implementation Method 2

performing crystallization processing on the supernatant and making analysis to obtain supernatant-related parameters

Methodology Applied

Scientific EffectCrystallization: Crystallisation

Data Source

PatentEP4679055A1Urine treatment method and urine detection system

Publication Date: 2026.01.14 JIANG HONGTAO

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AI summary

The present application provides a urine processing method and a urine testing system. The method comprises processing urine to obtain urinary sediment and supernatant, performing crystallization processing on the supernatant and making analysis to obtain supernatant-related parameters, and making comprehensive analysis through combination of the supernatant-related parameters with urinary sediment-related parameters and urine dry chemistry-related parameters. The system comprises a urine processing module configured to process urine to obtain urinary sediment and supernatant, and a supernatant analysis module configured to perform crystallization processing on the supernatant and make analysis to obtain supernatant-related parameters, and to make comprehensive analysis through combination of the supernatant-related parameters with the urinary sediment-related parameters and the urine dry chemistry-related parameters.