Urine Ion Analysis for COVID-19 Detection Without Viral Markers
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Solution Overview
Problem
Existing COVID-19 testing methods rely on detecting viral RNA, antibodies, or antigens, which are challenging for asymptomatic or pre-symptomatic individuals, and there is a need for a more effective and reliable method to detect the infection without these markers.
Innovation Solution
The method involves analyzing urine samples to measure mineral and ionic levels, using devices and kits that do not require COVID-19 RNA, antibodies, or antigens, and employs machine learning models to predict infection status based on ion concentration changes over time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If standard testing methods (RNA detection, antibody tests, antigen tests) are used to detect COVID-19, then viral infection can be detected, but the testing becomes complex, time-consuming, and less effective for asymptomatic individuals
Solution Approach 1:
The invention changes the detection parameter from viral markers (RNA, antibodies, antigens) to metabolic markers (urine composition, electrolyte levels, pH, specific gravity). This parameter transformation enables detection of COVID-19 through physiological changes in urine that occur during infection, providing a simpler alternative to complex molecular testing while maintaining detection capability for both symptomatic and asymptomatic cases
Solution Approach 2:
The invention extracts the detection target from viral materials (RNA, proteins) to metabolic waste products in urine. By removing the need for viral-specific markers and focusing on host physiological responses reflected in urine composition, the testing method becomes simpler, faster, and equally effective for detecting infection status
2Measurement precision
If RNA-based molecular testing is performed, then high sensitivity and specificity can be achieved, but the testing requires specialized equipment, trained personnel, and takes several hours to weeks
Solution Approach 1:
The invention employs disposable dipstick test strips for urine analysis instead of expensive, reusable molecular testing equipment. These simple, single-use strips provide rapid results without requiring sophisticated instrumentation or extensive processing time, making high-accuracy testing accessible and rapid
Solution Approach 2:
The invention replaces complex mechanical and biochemical systems (PCR machines, centrifuges, automated analyzers) with simple chemical test strips that rely on basic colorimetric reactions. This substitution dramatically reduces equipment requirements, operational complexity, and testing time while maintaining measurement precision through validated chemical assays
3Ease of operation
If saliva or swab samples are collected for testing, then viral RNA can be detected, but the sampling process is invasive and less convenient for at-home testing
Solution Approach 1:
The invention enables individuals to perform their own testing using urine samples, which can be collected privately and without assistance. The simple dipstick method requires no specialized training or equipment operation, allowing complete self-service testing at home while maintaining detection reliability through objective chemical measurements of urine parameters
Data Source
AI summary
The present invention generally includes methods, devices and/or kits for the detection of a COVID-19 infection in an individual by measuring the level or concentration or one or more ions present in a urine sample that is substantially free of COVID-19 RNA, antibodies, or antigen material.