Urine Ion Profiling for COVID-19 Detection Amid Competing Ions
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Solution Overview
Problem
Existing COVID-19 detection methods face challenges in accurately distinguishing between asymptomatic and pre-symptomatic individuals due to the inability to selectively measure ions in the presence of competing ions, leading to less accurate detection and measurement, especially when relying on RNA, antigens, or antibodies.
Innovation Solution
The method involves measuring and quantifying changes in mineral and ionic levels in urine samples without the need for SARS-CoV-2 virus, antibodies, or viral material, using devices and test strips to detect COVID-19 infection by analyzing urine samples for ions such as potassium and sodium.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If RNA, antigens, or antibodies are used for COVID-19 detection, then detection can be performed, but accuracy in distinguishing asymptomatic and pre-symptomatic individuals deteriorates due to inability to selectively measure ions in presence of competing ions
Solution Approach 1:
The invention segments the detection approach by using multiple specific ion measurements (sodium, potassium, calcium, magnesium) rather than relying on a single biomarker. This segmentation allows for a more nuanced detection profile that can distinguish between asymptomatic and pre-symptomatic individuals through patterns of ion level changes.
Solution Approach 2:
The invention uses ion level changes as intermediary markers that reflect physiological changes during COVID-19 infection. By measuring electrolyte levels in urine samples, the method detects indirect physiological responses to viral infection, which provides better differentiation capability compared to direct viral detection methods.
2Measurement precision
If standard ion detection methods are used, then ion measurement can be performed, but selectivity deteriorates due to presence of competing ions
Solution Approach 1:
The invention measures multiple ion parameters simultaneously (sodium, potassium, calcium, magnesium) and analyzes their relative changes and ratios. By examining patterns across multiple parameters rather than single ion concentrations, the method achieves selective detection despite the presence of competing ions in the urine sample.
Solution Approach 2:
The detection system performs multiple functions by simultaneously measuring different ion types and analyzing various aspects of ion level changes (absolute levels, ratios, temporal patterns). This multi-functional approach enables selective detection of COVID-19 related physiological changes while filtering out interference from competing ions.
Data Source
AI summary
The present invention generally includes methods, devices and/or kits for the detection of a COVID-19 infection in an individual by measuring the level or concentration or one or more ions present in a urine sample that is substantially free of COVID-19 RNA, antibodies, or antigen material.