Urine Sample Analysis Coordination for Adaptive Measurement Conditions

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Solution Overview

Problem

Existing urinalysis systems face inefficiencies in processing large volumes of samples due to the need to change measurement conditions based on qualitative analysis results, particularly in systems combining urinary qualitative and sediment tests, leading to challenges in achieving efficient and reliable multi-step analysis.

Innovation Solution

A sample analysis system comprising multiple analyzers with different measurement methods, where a first analyzer provides a color-based measurement result used to determine the sample amount for a second analyzer, allowing for optimized sample processing and efficient determination of additional measurements based on the first analyzer's results.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If measurement conditions of the urine sediment section are changed between two alternative conditions according to whether an analysis result of the qualitative analysis section is positive or negative, then analysis reliability is improved, but measurement efficiency deteriorates

Engineering Contradiction:
Improveanalysis reliabilityVSAvoidmeasurement efficiency
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent applies parameter changes by dividing the urine sediment analysis into multiple measurement stages with different parameters. For samples with positive qualitative analysis results, a first measurement condition is applied with specific parameters (measurement time, sample amount). For samples with negative results, a second measurement condition with different parameters is applied. This dynamic parameter adjustment based on qualitative analysis results optimizes both reliability and efficiency

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The system dynamically adjusts measurement conditions based on real-time analysis results from the qualitative section. The management device automatically determines which measurement condition to apply to the sediment section based on the qualitative analysis outcome, creating a dynamic adaptive measurement system that responds to sample characteristics

Inventive Principle:
Principle #15Dynamics

2Reliability

If a plurality of analyzers with different measurement methods are used for multi-step analysis, then analysis reliability is improved, but system complexity increases

Engineering Contradiction:
Improveanalysis reliabilityVSAvoidsystem complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The management device serves multiple functions: it manages the qualitative analysis section, controls the sediment analysis section, determines measurement conditions, and coordinates between different analyzers. This universal control system reduces overall system complexity by consolidating management functions in a single device rather than requiring separate control systems for each analyzer

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The management device acts as an intermediary between the qualitative analysis section and the sediment analysis section. It receives results from the first analyzer, processes this information, and determines appropriate measurement conditions for the second analyzer based on the qualitative analysis outcomes, thereby coordinating the multi-step analysis process

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If sample amount for the second analyzer is increased to improve measurement accuracy, then measurement precision is improved, but reagent consumption and processing time increase

Engineering Contradiction:
Improvemeasurement accuracyVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent applies local quality by adjusting the sample amount specifically for the sediment analysis section based on the qualitative analysis results, while keeping other measurement parameters optimized. For positive samples, a larger sample amount is provided to the sediment section to ensure accurate detection of sediment components. For negative samples, a smaller sample amount suffices, reducing processing time and reagent consumption without compromising overall measurement precision

Inventive Principle:
Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system enables efficient and reliable analysis by optimizing sample amounts and measurement conditions across different analyzers, reducing reagent and time consumption while enhancing the reliability of analytical results.

Implementation Method 1

a test strip that changes its color according to an amount of an analyte in the urine sample

Methodology Applied
Scientific EffectColor change: Absorption Spectroscopy

Data Source

PatentUS20250251408A1Sample analysis system and sample analysis method
Publication Date: 2025.08.07 SYSMEX CORP
  • US20250251408A1 patent drawing
  • US20250251408A1 patent drawing
  • US20250251408A1 patent drawing

AI summary

To provide a sample analysis method and a sample analysis system that can efficiently provide reliable assay results using a plurality of analyzer with different measurement methods. The sample analysis method for analyzing a sample using a plurality of analyzer (urine qualitative analyzer 10, urine particle analyzer 20 and imaging analyzer 30) the measuring method differs from each other includes a step of measuring a sample by the first analyzer, based on the first measurement result that varies according to the amount of analyte in the sample, and a step of determining the measurement conditions by the second analyzer.