Urine Sodium Feedback Control for Personalized Fluid Therapy

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Solution Overview

Problem

Conventional systems and methods for treating fluid overload fail to accurately monitor and respond to individual patient variations in urine output and sodium excretion, leading to sub-optimal diuretic and hydration fluid administration, which can prolong treatment time and exacerbate medical conditions.

Innovation Solution

A fluid management system that monitors urine output and sodium levels to adjust diuretic and hydration fluid administration based on an adjusted urine output rate, using sensors to determine the patient's actual urine sodium content and customize therapy for optimal fluid balance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional systems monitor urine output, then they can detect fluid overload, but they cannot accurately respond to individual patient variations in urine output and sodium excretion

Engineering Contradiction:

Improveaccuracy of urine output monitoringVSAvoidability to respond to individual patient variations

Core Design Contradiction:

Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The system changes the monitoring parameters from simple urine output volume to adjusted urine output rate that incorporates urine sodium concentration. This parameter transformation enables the system to account for individual patient variations in sodium excretion and respond accordingly to their specific physiological state.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The system implements continuous feedback by monitoring urine output and urine sodium concentration, then using this information to dynamically adjust diuretic and hydration fluid administration. This closed-loop feedback mechanism allows the system to adapt to individual patient responses in real-time.

Inventive Principle:

Principle #23Feedback

2Productivity

If diuretic dosage is increased to improve urine output, then fluid removal efficiency increases, but the risk of electrolyte imbalance and organ damage increases

Engineering Contradiction:

Improvefluid removal efficiencyVSAvoidelectrolyte imbalance and organ damage risk

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The system uses feedback from urine output rate and urine sodium concentration measurements to dynamically adjust diuretic dosage. This prevents excessive diuretic administration that could cause electrolyte imbalance, while still achieving adequate fluid removal when needed.

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The system monitors urine sodium concentration as a key parameter to determine appropriate diuretic dosing. By adjusting dosage based on actual urine sodium levels rather than fixed protocols, the system optimizes fluid removal while minimizing electrolyte disturbances.

Inventive Principle:

Principle #35Parameter changes

3Ease of operation

If fixed diuretic protocols are used to simplify treatment, then ease of operation improves, but treatment time increases and efficacy decreases

Engineering Contradiction:

Improvesimplicity of treatment protocolVSAvoidtreatment time

Core Design Contradiction:

Ease of operationVSLoss of time

Solution Approach 1:

The system performs self-adjustment by automatically modifying diuretic and hydration fluid rates based on monitored urine output and sodium concentration. This eliminates the need for complex manual protocols while reducing treatment time through automated optimization.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The system transitions from static fixed protocols to dynamic adjustable protocols where diuretic and fluid rates change in real-time based on patient response. This dynamic approach maintains ease of operation through automated control while significantly reducing treatment time.

Inventive Principle:

Principle #15Dynamics

4Reliability

If hydration fluid is administered to maintain fluid balance, then patient safety improves, but fluid overload risk increases

Engineering Contradiction:

Improvepatient safetyVSAvoidfluid volume

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The system uses feedback from urine output and urine sodium concentration to dynamically adjust hydration fluid rates. This ensures adequate hydration to maintain safety while preventing fluid overload by matching fluid administration to actual urine output and sodium excretion.

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The system adjusts hydration fluid rates based on monitored urine sodium concentration and output rate. This parameter-based adjustment optimizes fluid balance, maintaining patient safety while minimizing total fluid volume to prevent overload.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS12471842B2Fluid therapy based on adjusted urine output rate, and associated systems, devices, and methods

Publication Date: 2025.11.18 REPRIEVE CARDIOVASCULAR INC

AI summary

This present disclosure relates to fluid therapy based on adjusted urine output rate and/or sodium output rate, and associated systems, devices, and methods. Exemplary methods can include receiving a sodium excretion input for the patient; receiving a urine output rate; determining an adjusted urine output rate based on the sodium excretion input and the urine output rate; and providing fluid therapy based on the adjusted urine output rate. By determining the amount and/or rate of the infused diuretic and/or hydration fluid based on a patient's actual sodium excretion levels, embodiments of the present technology can optimize and/or customize all or a subset of a diuretic therapy to an individual patient's physiology.