Urolithin Stabilization Using Collagen Complexes

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Solution Overview

Problem

There is no effective method for stabilizing urolithins, which are known for their antioxidant, anti-inflammatory, and anti-saccharification effects, to maintain their stability and efficacy in preparations over a long period.

Innovation Solution

A urolithin-containing aqueous solution is developed with collagen, where the total amount of collagen is 0.1 to 100,000 parts by weight per part of urolithin, enhancing the stability of urolithins, and a method for producing this solution and its dried solid composition is provided, allowing for their use in cosmetics, pharmaceuticals, and other products.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional stabilization methods (chelating agents, cyclodextrin, ascorbic acid) are used for polyphenols, then preservation is improved, but no satisfactory stabilization is achieved for urolithins

Engineering Contradiction:

Improvestability of urolithinsVSAvoidapplicability of stabilization method

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical parameter by using collagen instead of conventional stabilizers like chelating agents or cyclodextrin. This parameter substitution resolves the contradiction by finding a material that specifically works for urolithins where other methods fail, achieving both reliability and adaptability.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

Collagen acts as an intermediary substance that mediates the stabilization of urolithins. The collagen-urolithin complex formed through this intermediary approach provides effective stabilization that direct methods with conventional agents cannot achieve.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If urolithins are added to preparations, then functional benefits (antioxidant, anti-inflammatory effects) are improved, but stability over time deteriorates

Engineering Contradiction:

Improvestability of urolithinsVSAvoidduration of efficacy maintenance

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies preliminary action by pre-forming a complex between collagen and urolithins before use. This preliminary complexation protects the urolithins from degradation during storage, ensuring that the functional benefits are maintained over extended periods without loss of stability.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent creates a composite material system consisting of collagen and urolithins in a specific ratio (0.1-100,000 parts collagen per part urolithin). This composite approach combines the stabilizing properties of collagen with the functional properties of urolithins, achieving both long-term stability and sustained efficacy.

Inventive Principle:

Principle #40Composite materials

3Reliability

If collagen is added to urolithin solution, then stability is improved, but formulation complexity increases

Engineering Contradiction:

Improvestability of urolithinsVSAvoidformulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

Collagen serves multiple functions simultaneously: it stabilizes urolithins, provides structural framework for the formulation, and can be sourced from various materials. This multi-functionality reduces overall formulation complexity despite adding collagen, as it replaces the need for multiple separate stabilizing agents.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentEP3412274B1Urolithins-containing aqueous solution, dried solid composition thereof and production method therefor, and urolithins stabilizing method

Publication Date: 2023.11.08 DAICEL CORP

AI summary

A urolithin-containing aqueous solution containing urolithin and collagen, a dried solid composition thereof, methods for producing these, and a stabilization method for urolithin.