Urolithin Derivative Structures Addressing Mitochondrial Dysfunction

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Solution Overview

Problem

Current treatments for neuronal and mitochondrial diseases lack effective compounds that can address mitochondrial dysfunction and related health conditions such as obesity, metabolic syndrome, diabetes, cardiovascular disease, neurodegenerative diseases, and liver dysfunction.

Innovation Solution

Development of urolithin derivatives with specific structural formulas (Ia to Ih) that can enhance mitochondrial function and neuronal health, including compounds with varying substituents and functional groups to improve bioavailability and efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current treatments for neuronal and mitochondrial diseases are used, then existing therapeutic options are available, but they lack effectiveness in addressing mitochondrial dysfunction and related health conditions

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidability to address mitochondrial dysfunction

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of urolithin through various substituents (R1-R8 groups including halogen, alkyl, hydroxyalkyl, aminoalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl groups) to create derivatives with enhanced mitochondrial activity and therapeutic effectiveness for neuronal and mitochondrial diseases

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates composite chemical structures by combining the core urolithin molecule with diverse functional groups and substituents, resulting in hybrid compounds that possess both the mitochondrial benefits of urolithin and additional properties from the attached groups, thereby improving versatility in treating multiple conditions

Inventive Principle:

Principle #40Composite materials

2Reliability

If urolithin derivatives with specific structural formulas are developed, then mitochondrial function and neuronal health can be enhanced, but the complexity of the compound structures increases

Engineering Contradiction:

Improvemitochondrial function enhancementVSAvoidstructural complexity of compounds

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent segments the complex molecule into a core urolithin structure with distinct substitutable positions (R1-R8), allowing systematic modification of specific regions while maintaining the essential mitochondrial-active core structure, thereby managing complexity through modular design

Inventive Principle:

Principle #1Segmentation

Data Source

PatentUS12358884B2Urolithin derivatives and methods of use thereof

Publication Date: 2025.07.15 AMAZENTIS SA

AI summary

Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.