Urolithin Emulsified Composition for Stable Liquid Solubilization
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Solution Overview
Problem
Existing methods struggle to solubilize urolithins effectively, requiring large amounts of cyclodextrin and failing to achieve stable dispersion in liquid compositions.
Innovation Solution
A method involving heating a solution of urolithins, an emulsifier with an HLB of 12.0 or greater, and a polyhydric alcohol at 120°C or higher for 1 minute or more, with a total emulsifier amount of 50 parts by weight or more, or heating at 105°C or higher for 1 minute or more with an HLB of 15.5 or greater and 500 parts by weight of emulsifier, to produce an emulsified composition with a transmittance of 40% or greater at 660 nm.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If cyclodextrin is used to solubilize urolithins, then solubility is improved, but a large amount of cyclodextrin is required and the method is not efficient
Solution Approach 1:
The invention changes the solubilization approach from using cyclodextrin (a different chemical mechanism) to using emulsifiers with specific HLB values (12.0 or greater, or 15.5 or greater). This parameter change in the type of solubilizing agent enables effective urolithin solubilization without requiring large amounts of additive, as the emulsifier forms stable emulsions that naturally solubilize the poorly water-soluble substance.
Solution Approach 2:
The invention adopts the successful emulsification approach from Patent Document 1 (which solved curcuminoid solubility) and adapts it to urolithins. By copying the emulsifier-based method and adjusting the HLB value parameters, the invention achieves similar effectiveness for urolithins without needing large amounts of cyclodextrin or other additives.
2Ease of manufacture
If urolithins are blended in powder or crystal form, then they can be used as is, but aggregation or precipitation occurs when blending in liquid compositions
Solution Approach 1:
The invention changes the physical state of urolithins from solid powder/crystal form to solubilized form in liquid composition. By adjusting the emulsifier HLB value parameter, the invention enables urolithins to be dissolved at the molecular level rather than existing as particles, eliminating aggregation and precipitation issues while maintaining ease of blending in liquid formulations.
3Quantity of substance
If high-temperature heating is applied to emulsify urolithins, then solubility is improved, but the emulsifier amount must be precisely controlled
Solution Approach 1:
The invention establishes specific HLB value ranges for emulsifiers (12.0 or greater, or 15.5 or greater) that enable effective urolithin solubilization through heating. By defining these parameter ranges, the invention simplifies the control process - instead of requiring precise control of emulsifier amount, manufacturers only need to ensure the emulsifier meets the HLB requirement, making the process more robust and easier to control.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method solubilizes urolithins, enhancing their bioavailability and allowing them to be blended in a solubilized state, improving stability and bioavailability in liquid compositions.
Implementation Method 1
heating a solution containing urolithins, an emulsifier, and a polyhydric alcohol
Implementation Method 2
heating a solution containing urolithins, an emulsifier, and a polyhydric alcohol
Implementation Method 3
heating a solution containing urolithins, an emulsifier, and a polyhydric alcohol at 120°C or higher for 1 minute or more
Data Source
AI summary
The present disclosure provides a technique for producing a composition in which at least urolithins are solubilized, and a method for producing an emulsified composition.