UV Plasma Irradiation Box for Selective Pathogen Inactivation
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Solution Overview
Problem
Current methods for treating viral and bacterial infections in blood plasma using UV irradiation are limited as they can damage red and white blood cells, and there is a need to combine UV Blood Irradiation (UBI) with Plasmapheresis to target only the plasma component, which has not been successfully achieved.
Innovation Solution
A UV box system that includes a housing with a plasma diffuser and UV light sources, designed to be integrated or connected with blood cleaning machines, allowing for the selective irradiation of blood plasma while protecting the cellular elements, using different wavelengths of UV light and configurations to optimize exposure and minimize damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If UV light is used to irradiate blood plasma to kill viruses and bacteria, then the pathogen destruction capability is improved, but the cellular elements (red and white blood cells) are damaged
Solution Approach 1:
The invention separates blood into plasma and cellular elements using a plasma separator before UV irradiation. The plasma is directed to the UV irradiation chamber while cellular elements are diverted away from the UV light path, allowing selective treatment of plasma without exposing blood cells to damaging radiation.
Solution Approach 2:
The invention extracts the plasma component from whole blood and subjects only this extracted portion to UV irradiation. This extraction approach allows the UV treatment to be applied selectively to the pathogen-containing plasma while leaving the cellular elements untouched and protected from radiation damage.
2Reliability
If UV Blood Irradiation (UBI) is applied to treat infections, then viral and bacterial neutralization is achieved, but the treatment cannot selectively target plasma without affecting other blood components
Solution Approach 1:
The invention merges plasmapheresis technology with UV Blood Irradiation to create an integrated system. The plasma separator from plasmapheresis is combined with the UV irradiation chamber, enabling the system to both separate plasma from blood and subsequently irradiate the plasma, achieving selective pathogen treatment with enhanced versatility.
Solution Approach 2:
The plasma separator acts as an intermediary device between the blood input and UV irradiation chamber. It mediates the separation process, directing plasma to the UV treatment path while routing cellular elements through a separate path, thereby enabling selective targeting of plasma without exposing other blood components to UV radiation.
3Productivity
If conventional UBI methods are used, then some infections are treated, but the inability to combine with plasmapheresis limits the effectiveness against antibiotic-resistant strains and novel viruses
Solution Approach 1:
The integrated system performs multiple functions: it separates plasma from blood, irradiates the plasma with UV light, and returns the treated plasma to the patient. This multi-functional approach combines plasmapheresis and UV irradiation capabilities in a single system, enhancing treatment effectiveness against resistant and novel pathogens while managing the complexity through unified design.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively inactivates pathogens in the plasma without damaging the cellular components, enabling a more targeted and efficient treatment of viral and bacterial infections, including antibiotic-resistant strains and novel viruses, by ensuring that only the plasma is exposed to UV radiation.
Implementation Method 1
Ultraviolet (UV) radiation is a potent source of energy, known to be capable of neutralizing or killing any virus or bacteria
Data Source
AI summary
The present invention is a UV light box, systems, and methods for irradiating plasma.