UV Absorber Precursor Composition for Faster Avobenzone Activation
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Solution Overview
Problem
Existing sunscreen formulations containing methoxyphenylethenyl t-butylbenzoate as a photochemical UV absorber precursor convert to avobenzone slowly and incompletely, leading to delayed UVA filter action.
Innovation Solution
Incorporating a phenylethyl ester, such as phenethyl benzoate, with benzoic acid esters like methoxyphenylethenyl t-butylbenzoate in sunscreen compositions enhances the photochemical conversion rate, providing quick and stable protection against both UVA and UVB radiation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If methoxyphenylethenyl t-butylbenzoate is used as a photochemical UV absorber precursor, then UVA filter action is provided, but conversion to avobenzone proceeds slowly and incompletely causing delayed action
Solution Approach 1:
The patent introduces a phenylethyl ester compound as an intermediary substance that catalyzes the photochemical conversion of methoxyphenylethenyl t-butylbenzoate to avobenzone. This intermediary accelerates the transformation rate, ensuring rapid activation of UVA filter protection without delay.
Solution Approach 2:
The patent modifies the chemical environment parameters by combining the precursor with specific phenylethyl ester compounds, changing the reaction conditions to favor faster and more complete conversion to the active UV absorber form.
2Reliability
If multiple individual sunscreen active agents are used in combinations at maximum concentrations, then higher SPF protection is achieved, but interactions between agents may occur
Solution Approach 1:
The patent extracts and utilizes the catalytic property of phenylethyl esters to enhance the conversion of a single precursor compound, achieving effective protection through one active ingredient system rather than multiple agents, thereby avoiding interactions while maintaining SPF efficacy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination with phenylethyl esters increases the photochemical conversion rate of benzoic acid esters to UV absorbers, maintaining absorbance values and enhancing photostability, ensuring effective UVA and UVB protection.
Implementation Method 1
They are susceptible to be photochemically converted in situ to a sunscreen active agent with enhanced UV protection ability
Implementation Method 2
Avobenzone (4-tert-butyl-4′-methoxydibenzoylmethane, Parsol 1789) is one of the most commonly used UVA filters since it provides superior protection through a large portion of the UVA range
Data Source
AI summary
A composition including an effective amount of a compound of formula (I), a pharmaceutically or a cosmetically acceptable salt thereof, or a stereoisomer of any of them or mixtures thereof,The composition further includes one or more pharmaceutically or cosmetically acceptable excipients or carriers. The composition can be used to provide protection for the skin or hair against the sun's rays or other sources of UV radiation. A method for increasing the photochemical conversion rate of a compound of formula (I) in a composition by adding an effective amount of the above mentioned specific phenylethyl ester.