Vaccinated Hen Egg Virus Production
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Solution Overview
Problem
Current methods for producing influenza vaccines face challenges in rapidly producing large quantities of the influenza virus, especially with the increasing economic incidence of avian influenza in domestic bird farms and the risk of highly pathogenic strains adapting to humans, which threatens the supply of eggs for vaccine manufacturing.
Innovation Solution
A process involving vaccinating chickens, obtaining eggs from vaccinated hens, triggering embryogenesis, infecting embryonated eggs with an influenza virus, and collecting the virus from the Allantoic fluid, which allows for the replication and production of the influenza virus under controlled conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If eggs from hens vaccinated against influenza are used for virus production, then the supply of eggs for vaccine manufacturing is secured, but maternal antibodies in the eggs were expected to interfere with virus replication
Solution Approach 1:
The patent converts the previously harmful maternal antibodies into a beneficial protective factor. By vaccinating hens against influenza, the maternal antibodies transferred to eggs protect the hen population from avian flu outbreaks, ensuring continuous egg supply for vaccine production. The harm (antibody interference) is transformed into benefit (disease protection in hens) while the virus production process remains effective.
2Productivity
If large quantities of influenza virus are produced rapidly, then vaccine manufacturing needs are met, but the risk of highly pathogenic strains adapting to humans increases
Solution Approach 1:
The patent implements preliminary vaccination of hens against influenza before using their eggs for virus production. This proactive measure protects the hen population from highly pathogenic avian influenza strains, preventing potential adaptation and transmission to humans. The protective action is taken in advance, before any exposure to pathogenic strains occurs.
3Reliability
If hens are vaccinated against influenza, then protection against avian flu is achieved, but the complexity of the production process increases
Solution Approach 1:
The patent employs a self-service approach where hens automatically receive protection through vaccination, and their eggs naturally contain the protective maternal antibodies. The hens serve themselves by producing vaccinated eggs that inherently protect against influenza without requiring additional intervention during the egg collection and virus production process. This simplifies the overall system while maintaining protection efficacy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method enables the rapid and large-scale production of influenza virus, ensuring a consistent supply for vaccine manufacturing while protecting chickens against avian flu, and can be used to produce vaccines for both human and animal influenza strains.
Implementation Method 1
infecting embryonated eggs with an influenza virus, and collecting the virus from the Allantoic fluid, which allows for the replication and production of the influenza virus under controlled conditions
Data Source
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AI summary
The invention relates to a method for producing the flu virus, that comprises: a) administering a flu vaccine to hens; b) collecting the eggs of the vaccinated hens; c) triggering the embryogenesis process; d) infecting the embryonated eggs by inoculating a flu virus in the allantoic cavity; e) incubating the infected embryonated eggs in temperature and humidity conditions allowing the virus replication; and f) collecting the allantoic liquid containing the virus.