Vacuum Effervescent Granule Production Control

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Solution Overview

Problem

Existing methods for producing effervescent granules lack standardized, reproducible process control, leading to uncontrollable reactions and inefficient production due to variations in raw material qualities and batch-specific differences, making automation challenging.

Innovation Solution

The method involves reacting reactive constituents in a vacuum within a specified pressure range (200-900 mbar) with controlled evacuation cycles, allowing for precise control of the reaction by adjusting vacuum values and cycle parameters, enabling automated, batch-to-batch consistency without intermediate drying.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the reaction is carried out at atmospheric pressure with stepwise addition of liquid, then the reaction can be better controlled, but the production time is much too slow for efficient production

Engineering Contradiction:
Improvereaction controlVSAvoidproduction time
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent applies parameter changes by conducting the reaction in a vacuum environment (reduced pressure) rather than at atmospheric pressure. This parameter change accelerates the reaction rate and allows for more efficient production while maintaining control through the vacuum conditions, directly resolving the contradiction between reaction control and production time.

Inventive Principle:
Principle #35Parameter changes

2Duration of action of moving object

If the reaction takes place under atmospheric pressure for 25-40 minutes, then the reaction can proceed, but it is uncontrollable and too slow for efficient production

Engineering Contradiction:
Improvereaction durationVSAvoidreaction controllability
Core Design Contradiction:
Duration of action of moving objectVSReliability

Solution Approach 1:

The patent changes the pressure parameter from atmospheric to vacuum conditions, which fundamentally alters the reaction kinetics and controllability. The vacuum environment enables the reaction to proceed under controlled conditions with appropriate duration, resolving both the time and controllability issues simultaneously.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs periodic action through cyclic evacuation and pressure equalization during the reaction process. This periodic modulation of pressure conditions allows for controlled reaction progression, preventing uncontrolled reactions while maintaining efficient production rates.

Inventive Principle:
Principle #19Periodic action

3Reliability

If intermediate drying and repeated addition of liquid is used to control the reaction, then the reaction can be managed, but the production time is lengthened in an undesired manner

Engineering Contradiction:
Improvereaction controlVSAvoidproduction time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent achieves continuous reaction progression under vacuum conditions without requiring intermediate drying steps. The vacuum environment maintains appropriate moisture levels and reaction conditions continuously, eliminating time-consuming intermediate steps while preserving reaction control.

Inventive Principle:
Principle #20Continuity of useful action

4Loss of substance

If the vacuum is as low as possible (10-20 mbar) during vacuum treatment, then the solvent can be removed, but the reaction can easily lead to overreaction and undesired considerable granulation

Engineering Contradiction:
Improvesolvent removalVSAvoidreaction control precision
Core Design Contradiction:
Loss of substanceVSManufacturing precision

Solution Approach 1:

The patent applies dynamics by using a modifiable vacuum level rather than a fixed extreme vacuum. The vacuum pressure is dynamically adjusted to appropriate levels that balance solvent removal with prevention of overreaction, allowing flexible control of the reaction process.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent employs periodic evacuation cycles with specific vacuum levels rather than continuous extreme vacuum. This periodic action with controlled vacuum intensity prevents overreaction and unwanted granulation while still achieving adequate solvent removal through repeated cycles.

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for controlled and reproducible reactions, preventing overreaction and agglomeration, significantly reducing production time and enabling fully automated, computer-controlled production of effervescent granules with improved stability and consistency.

Implementation Method 1

the reactants are reacted in a vacuum in an evacuatable container with evolution of gas

Methodology Applied
Scientific EffectVacuum: Vacuum

Implementation Method 2

the pressure in the container due to the gasses forming during the reaction is then allowed to increase with a specified pressure difference up to a second vacuum value

Methodology Applied
Scientific EffectPressure difference: Pressure Gradient

Implementation Method 3

Effervescent granules and effervescent tablets can be prepared by mixing of alkaline constituents eliminating carbon dioxide, in particular bicarbonates or carbonates, with preferably edible, organic acids

Methodology Applied
Scientific EffectChemical reaction: Chemical Bonding

Implementation Method 4

reacted in a vacuum in an evacuatable container with evolution of gas

Methodology Applied
Scientific EffectGas evolution: Decomposition (biological)

Data Source

PatentUS7972623B2Method for the production of effervescent granules in a vacuum
Publication Date: 2011.07.05 HERMES PHARMA M B H

AI summary

The invention relates to a method for producing effervescent granules, in which the reaction partners edible, organic acid components and alkaline effervescent components separating carbon dioxide are reacted with each other in a vacuum under the effect of gas in a container that can be evacuated. The container is evacuated to a first vacuum value within a vacuum range of 200-900 mbar, whereupon the pressure inside the container is increased to a second vacuum value as a result of the gases produced during the reaction. The steps are cyclically repeated while the reaction continues. A maximum number of cycles, a maximum reaction time, and optionally, a maximum load for the stirring apparatus are defined before the reaction begins, and the reaction is terminated after reaching the first of the maximums. In an alternative embodiment, the invention also relates to a method for improving the shelf life of effervescent granules by a treatment with carbon dioxide during and/or following the production of the effervescent granules, and effervescent particles treated in this manner.