VAE Prediction System Using Machine Learning

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Solution Overview

Problem

Current methods for detecting ventilator-associated events (VAEs) are subjective and limited, often detecting complications only after they have occurred, which delays timely interventions and increases patient morbidity and mortality.

Innovation Solution

A system that uses medical data, including patient demographics, ventilator settings, and clinical observations, to predict VAEs through automated processing and machine learning models, allowing for proactive identification of potential complications.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional NHSN Pneumonia criteria are used for VAP detection, then the detection process is simple and relies on radiologist judgment, but the detection is subjective, insensitive, and delays timely intervention

Engineering Contradiction:
ImproveVAE detection accuracyVSAvoiddetection system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent replaces subjective radiologist judgment and manual clinical assessment with an automated machine learning-based detection system. The system processes multiple data streams (vital signs, ventilator parameters, lab results, imaging) through computational algorithms to objectively identify VAEs, eliminating human subjectivity while maintaining comprehensive analysis capability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The detection system is designed to handle multiple data types and patient populations simultaneously. It integrates diverse data sources including vital signs, ventilator settings, laboratory results, and imaging data, and can adapt to different patient demographics and clinical scenarios through its universal machine learning model.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Reliability

If NHSN PNEU criteria with multiple pathways are used, then the system can accommodate different patient populations, but the criteria are non-specific, insensitive, and have poor correlation with histologic pneumonia

Engineering Contradiction:
ImproveVAE detection reliabilityVSAvoidclinical information completeness
Core Design Contradiction:
ReliabilityVSLoss of information

Solution Approach 1:

The system segments the detection task into multiple independent analysis modules, each processing specific data types (vital signs, ventilator parameters, lab results, imaging). This allows comprehensive evaluation of multiple clinical dimensions simultaneously while maintaining organized data flow and processing efficiency.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The machine learning model serves as an intermediary that synthesizes information from diverse data sources. It processes raw clinical data through computational algorithms to generate integrated VAE probability assessments, bridging the gap between disparate data types and clinical judgment.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Loss of time

If VAE detection is performed using traditional methods, then the current workflow is maintained, but VAEs are detected only after occurrence, delaying intervention and increasing morbidity and mortality

Engineering Contradiction:
Improvetime to VAE detectionVSAvoidclinical intervention efficiency
Core Design Contradiction:
Loss of timeVSProductivity

Solution Approach 1:

The system performs continuous real-time monitoring and prediction of VAE risk before actual complications occur. By analyzing trends in vital signs, ventilator parameters, and other clinical data streams, the system identifies patients at high risk of developing VAEs and alerts clinicians proactively, enabling preventive intervention before the event manifests.

Inventive Principle:
Principle #10Preliminary action

4Loss of time

If automated machine learning systems are implemented for VAE prediction, then early prediction and proactive intervention are enabled, but the system complexity and data processing requirements increase

Engineering Contradiction:
Improvetime to VAE predictionVSAvoidprediction system complexity
Core Design Contradiction:
Loss of timeVSDevice complexity

Solution Approach 1:

The system automatically extracts, processes, and analyzes clinical data without requiring manual intervention. It self-manages data collection from multiple sources, performs feature extraction and model inference autonomously, and generates predictions independently, reducing the operational burden on clinical staff while maintaining high predictive accuracy.

Inventive Principle:
Principle #25Self-service

Data Source

PatentUS12318540B2Prediction of ventilator-associated events (VAEs)
Publication Date: 2025.06.03 KONINKLIJKE PHILIPS NV
  • US12318540B2 patent drawing
  • US12318540B2 patent drawing
  • US12318540B2 patent drawing

AI summary

Described herein are methods, devices and systems for predicting ventilator associated events (VAEs). In an example, data of a patient including one or more features useful in predicting VAEs is accessed and the features are extracted. The extracted features are evaluated automatically to determine a probability that a VAE will occur. If it is determined, based on the evaluating, that a VAE has a probability of occurring that exceeds a threshold, an indication that the VAE is predicted to occur is provided. Other examples are disclosed and claimed.