Vandateroside Isolation for Mitochondrial Stimulation
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Solution Overview
Problem
Current cosmetic and dermatological products lack effective molecules that can stimulate mitochondrial function and promote skin health, particularly in addressing skin aging and hydration, with no isolated active molecules from Papilionanthe teres being identified for these purposes.
Innovation Solution
The isolation and characterization of new compounds, referred to as vandaterosides, derived from Papilionanthe teres, which stimulate the mitochondrial respiratory chain, enhance cellular differentiation, and improve skin hydration and renewal, are incorporated into cosmetic or dermatological compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic active ingredients are used to stimulate mitochondrial function, then cellular energy metabolism is activated, but the effectiveness is insufficient compared to isolated active molecules
Solution Approach 1:
The patent extracts and isolates the specific active molecule eucomic acid from the Papilionanthe teres plant extract. This extraction process concentrates the bioactive compound responsible for mitochondrial stimulation, transforming a dilute plant extract into a purified active ingredient with enhanced effectiveness and standardized concentration.
2Adaptability or versatility
If plant extracts are used as active agents, then cosmetic activity is achieved, but the specific active molecules remain unidentified
Solution Approach 1:
The patent replaces empirical testing of whole plant extracts with targeted analysis using analytical chemistry techniques (HPLC, NMR, mass spectrometry). This substitution of mechanical/biological testing with instrumental analysis enables precise identification of eucomic acid as the active molecule, providing structural characterization and confirming its identity.
3Use of energy by moving object
If mitochondrial function is stimulated to combat skin aging, then cellular energy production improves, but oxidative stress increases
Solution Approach 1:
The patent leverages the dual effect of eucomic acid by utilizing its ability to stimulate mitochondrial function while simultaneously managing the associated oxidative stress. The active molecule activates cellular energy metabolism through mitochondrial respiratory chain stimulation, and this same mechanism promotes healthy cellular turnover and differentiation, converting the potential harm of increased ROS into beneficial anti-aging effects.
Data Source
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AI summary
The invention relates to novel eucomic acid (2-(4-hydroxybenzyl)malic acid) derivatives or plant extracts comprising such derivatives, and also to cosmetic or dermatological compositions containing these compounds or these extracts, and to cosmetic care methods using said compositions. The invention relates in particular to compounds characterized in that they are represented by formula (I) below: (I) in which, with the proviso that R1, R2 and R3 are not simultaneously a hydrogen atom, R1 and R3 each independently represent a hydrogen atom or a saturated or unsaturated, preferably C1-C12, hydrocarbon-based chain comprising an aromatic group, preferably a phenyl, said aromatic group being preferably substituted with a group comprising a sugar, preferably a monosaccharide or disaccharide, said chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N, and R2 represents a hydrogen atom or a sugar, preferably a monosaccharide or disaccharide, said sugar being optionally substituted, in particular with a residue comprising a saturated or unsaturated, preferably C1-C12, hydrocarbon-based chain itself comprising an aromatic group, preferably a phenyl, said hydrocarbon-based chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N.