Vaporization Dose Unit for Controlled Pulmonary Drug Delivery

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current methods for delivering bioactive agents, such as dronabinol, face challenges due to low bioavailability and uncontrollable efficacy when administered orally or via injection, and existing vaporization devices lack the ability to accurately and reproducibly control the amount of bioactive agent inhaled.

Innovation Solution

A dose unit comprising a pallet with an isolated bioactive agent applied on a carrier material in thermal contact with a heating element, configured to vaporize a predetermined amount of the agent for pulmonary delivery, along with devices and methods for preparing and releasing the dose unit for inhalation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If oral ingestion or injection methods are used to deliver bioactive agents, then the delivery can be administered through conventional routes, but the bioavailability is low and efficacy is uncontrollable

Engineering Contradiction:

Improvebioavailability and efficacy controlVSAvoidadministration convenience

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces conventional mechanical delivery systems (oral ingestion, injection) with a vaporization-based pulmonary delivery system. The heating element vaporizes the bioactive agent, and the user inhales the vapor through the cartridge, enabling direct absorption into the bloodstream through the lungs for rapid and controllable efficacy.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent changes the delivery parameter from gastrointestinal absorption or intravenous injection to pulmonary vaporization and inhalation. This parameter change enables rapid onset of action (within minutes) and allows precise control over the amount of bioactive agent delivered through controlled heating and inhalation.

Inventive Principle:

Principle #35Parameter changes

2Productivity

If vaporization is performed at high temperature to ensure efficient delivery, then the bioactive agent is effectively vaporized, but toxic compounds are generated through combustion

Engineering Contradiction:

Improvevaporization efficiencyVSAvoidtoxic compound formation

Core Design Contradiction:

ProductivityVSObject-generated harmful factors

Solution Approach 1:

The patent precisely controls the heating temperature parameter to remain below the combustion point of the bioactive agent. The heating element is designed to vaporize the agent at controlled temperatures, preventing pyrolysis and formation of toxic compounds such as carbon monoxide, polynuclear aromatic hydrocarbons, benzene, and tar.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the potential harm of high-temperature combustion into benefit by using controlled low-temperature vaporization. This approach achieves efficient delivery of the bioactive agent in vapor form without generating toxic combustion products, turning what could be a harmful process into a safe and effective delivery method.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Manufacturing precision

If a predetermined dosage is provided in the cartridge, then the amount of bioactive agent is controlled, but the delivery amount varies due to user inhalation patterns

Engineering Contradiction:

Improvedosage controlVSAvoidactual delivered dose consistency

Core Design Contradiction:

Manufacturing precisionVSReliability

Solution Approach 1:

The patent incorporates feedback mechanisms where the device monitors and tracks the vaporization process and user inhalation patterns. This allows the system to adjust heating parameters in real-time to ensure consistent delivery of the predetermined dosage, compensating for variations in user inhalation dynamics.

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The patent pre-loads the cartridge with a precisely measured amount of bioactive agent and pre-configures the heating element to deliver the exact predetermined dosage. The system is designed to vaporize and deliver the complete loaded dose through controlled heating, ensuring that the full predetermined amount is delivered regardless of slight variations in user inhalation patterns.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution enables controlled and reproducible pulmonary delivery of bioactive agents, improving bioavailability and reducing the risks associated with uncontrolled administration, thus providing a more effective and reliable treatment option.

Implementation Method 1

a heating element, configured to vaporize a predetermined amount of the agent for pulmonary delivery

Methodology Applied

Scientific EffectVaporization: Evaporation

Data Source

PatentUS20250170058A1Method and device for vaporization and inhalation of isolated substances

Publication Date: 2025.05.29 SYQE MEDICAL LTD

AI summary

A dose unit including at least one isolated bioactive agent applied on a carrier material in thermal contact with an electrically heating element configured to vaporize a pre-determined amount of the agent for pulmonary delivery thereof is provided herein, as well as devices for effecting vaporization and pulmonary delivery of the isolated agent, and methods for preparing the dose unit, controllably releasing the agent therefrom, methods for pulmonary delivery thereof and methods of treatment of medical conditions treatable by pulmonary delivery of the isolated bioactive agent.