Variable Collecting Volume Chromatography Assembly
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Solution Overview
Problem
In multi-dimensional chromatography assemblies, the collecting volume often becomes full, leading to premature entry of components into the second separating column, which is undesirable, and using a larger volume prolongs the transfer time, while a smaller volume increases analysis time due to reduced fluid flow.
Innovation Solution
A variable collecting volume, which can be adapted by using exchangeable pipes, capillaries, or modules, allows for optimal sizing based on the first separating column and application conditions, with optional heating and dual collecting volumes for simultaneous collection and transfer, utilizing controlled fluid flow and pressure adjustments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a larger collecting volume is used, then the risk of premature component entry into the second separating column is reduced, but the transfer time increases
Solution Approach 1:
The patent applies dynamics by making the collecting volume adjustable rather than fixed. The system allows dynamic modification of the collecting volume size to match different operating conditions and column configurations, enabling optimization between collection accuracy and transfer time for each specific application scenario
Solution Approach 2:
The patent implements parameter changes by allowing the collecting volume parameter to be varied according to the first separating column characteristics and application requirements. This enables the system to adapt the volume parameter to achieve optimal performance without being constrained by a fixed design
2Loss of time
If a smaller collecting volume is used, then the transfer time is reduced, but components may enter the second separating column prematurely
Solution Approach 1:
The system uses dynamics by enabling real-time or pre-configured adjustment of the collecting volume based on the specific analytical requirements, allowing the volume to be optimized for speed when appropriate while maintaining reliability when needed
Solution Approach 2:
The patent applies parameter changes by making the collecting volume a variable parameter that can be tailored to each application, allowing users to select smaller volumes for rapid analysis when the analytical conditions permit
3Device complexity
If the collecting volume is fixed, then the device complexity is reduced, but the system cannot be adapted to different column configurations and applications
Solution Approach 1:
The patent applies segmentation by dividing the collecting volume into modular, exchangeable components (such as replaceable capillaries or modules). This allows the system to maintain simple operation while enabling adaptation to different applications through component interchange rather than complex integrated adjustments
Solution Approach 2:
The system implements universality by designing the collecting volume with exchangeable components that can be configured for different applications and column types. A single base system can serve multiple functions by swapping the appropriate volume component for the specific analytical requirements
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances accuracy and reduces analysis time by optimizing the collecting volume size according to the chromatography conditions, ensuring efficient transfer of components to the second separating column without increasing measurement duration.
Implementation Method 1
a fluid source (22) having a flow or pressure control for generating a fluid flow
Data Source
AI summary
Chromatography assembly for multi-dimensional chromatography, includes a first separating column (12; 112) for separating a sample into components; a second separating column (13; 114) having different separating characteristics for further separating the components separated in the first separating column (12; 112); a collecting volume (20; 120, 121) for collecting the components from the first separating column (12; 112) before entering the second separating column (14; 114); a switching assembly (22, 24; 122, 124) for switching from a first state (FIG. 1; FIG. 3), where the components leaving the first separating column (12; 112) are collected in the collecting volume (20; 120, 121) to a second state (FIG. 2; FIG. 4) where the components collected in the collecting volume (20; 120, 121) are transferred to the second separating column (14; 114); and a detector (18; 118) for detecting sample components leaving the second separating column (14; 114). The volume of the collecting volume (20; 120, 121) is variable. A further collecting volume (121) may be provided and fluid flow can be through the first collecting volume (120) in the first state and through the second collecting volume (121) in the second state.