Variable Density Particulate Tissue Graft for Prolonged Repair

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Solution Overview

Problem

Existing tissue graft compositions made from extracellular matrices (ECMs) are rapidly resorbed, limiting their influence on the restoration and repair of damaged or missing tissues, as they provide an initial rapid repair response but are no longer available to support the slower restoration of connective tissue elements.

Innovation Solution

Development of bioresorbable particulate tissue graft compositions with varying densities, where lower density particles resorb quickly to initiate repair and higher density particles resorb more slowly to prolong the ECM's influence on the restoration process, allowing for a tailored bioresorption profile to support complete tissue repair.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If ECM tissue graft compositions are used to repair damaged tissues, then initial rapid repair response is provided, but the graft is rapidly resorbed and no longer available to support slower restoration of connective tissue elements

Engineering Contradiction:

Improveinitial repair response rateVSAvoidgraft influence duration

Core Design Contradiction:

SpeedVSDuration of action of moving object

Solution Approach 1:

The tissue graft composition is segmented into multiple particle populations with different density ranges (first population: lower density, second population: higher density). This segmentation allows different portions of the graft to resorb at different rates, with lower density particles providing rapid initial repair response and higher density particles providing prolonged support for connective tissue restoration.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Different regions of the graft composition have different properties through the inclusion of particles with varying densities. The lower density particles are distributed to provide rapid resorption and initial repair, while higher density particles are distributed to provide sustained presence and prolonged influence on connective tissue restoration, creating local quality variations within the graft.

Inventive Principle:

Principle #3Local quality

2Ease of manufacture

If single-density ECM particles are used, then manufacturing is simpler, but the graft cannot provide both rapid initial repair and prolonged support for connective tissue restoration

Engineering Contradiction:

Improvegraft manufacturing complexityVSAvoidbioresorption profile tailoring

Core Design Contradiction:

Ease of manufactureVSAdaptability or versatility

Solution Approach 1:

The invention changes the density parameter of the ECM particles to create multiple populations with different resorption characteristics. By controlling particle density as a key parameter, the graft can be tailored to provide both rapid initial repair response and prolonged support for connective tissue restoration, enhancing adaptability while maintaining manageable manufacturing complexity through controlled parameter variation.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS11013829B2Particulate tissue graft with components of differing density and methods of making and using the same

Publication Date: 2021.05.25 ACELL INC

AI summary

Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.