Variable Sampling Rate for Hypoglycemic Alarm Accuracy

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Solution Overview

Problem

Continuous glucose monitors (CGMs) face challenges in accurately detecting hypoglycemic events due to false positive and false negative alarms, which can lead to user distrust and potential harm from incorrect therapeutic actions.

Innovation Solution

The method involves establishing predetermined thresholds and rates of change in glucose concentration to calculate a critical sampling rate, adjusting the sampling rate based on actual glucose changes, and triggering a hypoglycemic alarm within a targeted glucose concentration interval to minimize false alarms.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a continuous glucose monitor uses a fixed sampling rate to detect hypoglycemic events, then the detection speed is consistent, but false positive and false negative alarms increase due to varying actual glucose change rates

Engineering Contradiction:
Improvehypoglycemic event detection accuracyVSAvoidalarm system reliability
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The patent applies dynamics by transitioning from a fixed sampling rate to a variable sampling rate that adapts to the actual glucose change rate. The system dynamically adjusts the sampling rate based on measured glucose values: when glucose changes rapidly, the sampling rate increases to capture the trend accurately; when glucose is stable, the sampling rate decreases to reduce false alarms. This dynamic adaptation resolves the contradiction between detection speed and alarm reliability.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent changes the sampling rate parameter based on the actual glucose change rate. By calculating the rate of glucose change from sequential measurements and comparing it to a threshold, the system modifies the sampling rate parameter to optimize detection accuracy. This parameter change strategy allows the system to maintain high detection accuracy during rapid glucose changes while reducing false alarms during stable periods.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If the sampling rate is increased to capture rapid glucose changes, then false negative alarms are reduced, but the device complexity and energy consumption increase

Engineering Contradiction:
Improvefalse negative alarm reductionVSAvoidsampling rate management complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The system uses dynamic sampling rate adjustment based on glucose change detection. When the glucose change rate exceeds a threshold, the sampling rate is increased to prevent false negative alarms. When glucose levels are stable, the sampling rate is reduced. This dynamic approach maintains reliability during critical events while simplifying operation during normal conditions.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The sampling rate parameter is changed based on the calculated glucose change rate. The system monitors glucose values and adjusts the sampling interval parameter accordingly, increasing frequency during rapid changes and decreasing it during stability. This parameter adaptation reduces device complexity by using simple threshold-based logic rather than complex continuous adjustment mechanisms.

Inventive Principle:
Principle #35Parameter changes

3Ease of operation

If a fixed alarm threshold is used, then the alarm activation is simple, but false positive alarms occur when glucose temporarily fluctuates near the threshold

Engineering Contradiction:
Improvealarm threshold setting simplicityVSAvoidalarm activation accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The system performs preliminary action by calculating the glucose change rate before triggering the alarm. Instead of simply comparing glucose level to a threshold, the system first assesses whether glucose is changing rapidly. Only when both conditions are met (low glucose level and rapid decline) does the alarm activate. This preliminary assessment prevents false positive alarms from temporary fluctuations.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The glucose change rate serves as an intermediary parameter between the glucose level and alarm activation. Rather than directly comparing glucose level to threshold, the system uses the change rate as an intermediate criterion. This intermediary mechanism filters out false alarms caused by temporary fluctuations while maintaining simple threshold-based operation.

Inventive Principle:
Principle #24Intermediary (Mediator)

Data Source

PatentUS8439837B2Systems and methods for detecting hypoglycemic events having a reduced incidence of false alarms
Publication Date: 2013.05.14 LIFESCAN ENTERPRISES LLC
  • US8439837B2 patent drawing
  • US8439837B2 patent drawing
  • US8439837B2 patent drawing

AI summary

The present invention is directed to a method of reducing false readings in a hypoglycemic detector that includes establishing a predetermined hypoglycemic threshold, a predetermined critical threshold, a predetermined rate of change in glucose concentration where the predetermined critical threshold is below the predetermined hypoglycemic threshold. A first sampling rate is then calculated based upon said predetermined hypoglycemic threshold, said predetermined critical threshold, and said predetermined rate of change in glucose concentration.