Vascular Device Functionalized Surface Charge Density
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Solution Overview
Problem
Vascular devices, such as stents, face complications like thrombus formation and restenosis due to surface impurities and protein adsorption, which can lead to adverse reactions in the body, and existing solutions are costly and difficult to manufacture with stable surface characteristics.
Innovation Solution
A vascular device with a functionalized surface featuring double or more charged ions, which are exposed to bodily fluids, reducing thrombogenicity and improving biocompatibility, and a soluble surface sealing to maintain the surface characteristics during handling and insertion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the vascular device surface is provided with surface coatings or adapted surface structures to reduce thrombus formation and improve biocompatibility, then the biological acceptance and healing phase are improved, but the manufacturing cost increases and the surface becomes difficult to clean during handling and storage
Solution Approach 1:
The patent applies parameter changes by modifying the surface charge density of the vascular device surface. The surface is engineered to exhibit a positive surface charge density in the range of 0.03 to 0.05 N/m, which is a specific parameter change from conventional neutral or negatively charged surfaces. This parameter modification reduces fibrinogen adhesion and improves biocompatibility without requiring complex coatings or microstructures, thereby avoiding increased manufacturing costs and cleaning difficulties
2Object-affected harmful factors
If the vascular device surface is provided with surface coatings or adapted surface structures to reduce thrombus formation, then the inflammatory response is reduced, but the surface becomes difficult to clean during handling, storage and implantation
Solution Approach 1:
The patent modifies the surface charge density parameter to a specific positive range (0.03 to 0.05 N/m) that reduces inflammatory response and fibrinogen adhesion. This parameter-based approach maintains a relatively simple surface topology compared to complex coatings or microstructures, thereby preserving ease of cleaning during handling, storage, and implantation procedures
3Reliability
If the vascular device surface is modified to reduce protein adsorption and improve healing phase, then the biological acceptance is improved, but the manufacturing process becomes more complex and costly
Solution Approach 1:
The patent achieves improved healing phase outcomes by changing the surface charge density parameter to a specific positive range (0.03 to 0.05 N/m). This single parameter modification approach avoids the need for complex multi-layer coatings, microstructures, or sophisticated surface treatments, thereby reducing device complexity and manufacturing costs while maintaining improved biological acceptance and healing characteristics
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The vascular device effectively reduces thrombus formation and improves biocompatibility, allowing for easier manufacturing and handling while maintaining antithrombotic properties over its lifecycle.
Implementation Method 1
the surface of the vascular device is provided with double or more charged ions such that the ions are exposed to a bodily fluid when the vascular device is inserted in the body lumen
Data Source
AI summary
A vascular device for insertion in a body lumen, wherein the device includes a surface including at least a portion that is a functionalized surface provided with double or more charged ions such that the ions are exposed to a bodily fluid when the vascular device is inserted in the body lumen. The vascular device allows for reducing complications in its use and, particularly, for improving a desired healing in the body and preventing restenosis. At the same time, it allows for being manufactured at comparably low effort and for a convenient handling.