Vascular Hemodynamic Bionic Cell Experiment Device
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Solution Overview
Problem
Existing devices for vascular hemodynamic bionic cell experiments lack versatility and consistency in simulating different fluid and cell conditions, making them inadequate for comparative studies under varying experimental conditions.
Innovation Solution
A device comprising a cabinet with a circulation fluid shunting drive system and an experiment observation system, including a shunting bottle, collection bottle, peristaltic pump, and temperature control, allows for the simulation of multiple conditions by providing circulation fluid and temperature control, enabling the observation of living cells under various conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a customized device is developed for each lab's specific experimental requirements, then the device can meet specific experimental needs, but the device complexity increases and versatility decreases
Solution Approach 1:
The device is designed with a universal structure that can accommodate multiple experimental configurations. The flow chamber platform can support different cell types and fluid flow conditions through a standardized interface system, allowing one device to serve multiple laboratory needs without requiring custom-built devices for each specific experiment
Solution Approach 2:
The device is divided into modular components including a cabinet, circulation fluid shunting drive system, experiment observation system, and temperature control device. Each module can be independently configured and adjusted to meet different experimental requirements, reducing overall device complexity while maintaining versatility
2Adaptability or versatility
If multiple types of cells are cultured in the same fluid environment under hemodynamic force, then comparative study is enabled, but ensuring experiment consistency becomes difficult
Solution Approach 1:
The circulation fluid system is divided into multiple independent channels with separate flow control mechanisms. Each channel can be independently regulated to provide precise control over fluid flow conditions for different cell types, ensuring consistent experimental conditions while enabling comparative studies
Solution Approach 2:
The device incorporates temperature control devices and flow monitoring systems that provide real-time feedback. The temperature control device maintains constant temperature conditions, while flow monitoring ensures consistent hemodynamic forces are applied, thereby ensuring experiment consistency across multiple cell types
3Adaptability or versatility
If different fluid environments are provided for the same cell type, then comparative study under different conditions is enabled, but device complexity increases
Solution Approach 1:
The circulation fluid shunting drive system is designed as a universal platform that can provide multiple fluid environments through a single system. The system uses a shunting bottle with multiple chambers that can be configured to provide different fluid compositions and flow rates, eliminating the need for separate devices for each fluid condition
Solution Approach 2:
The device incorporates adjustable flow rates and variable fluid compositions through the shunting bottle system. The peristaltic pump can be adjusted to provide different flow rates, and the shunting bottle can be configured to provide different fluid environments, allowing dynamic adaptation to various experimental conditions without increasing device complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables efficient and versatile vascular hemodynamic bionic cell experiments by maintaining consistent conditions and allowing for the simultaneous comparison of cells under different fluid environments, enhancing experiment consistency and versatility.
Implementation Method 1
a peristaltic pump; each independent chamber of the collection bottle is connected to a shunting chamber of the shunting bottle respectively through the multi-channel peristaltic tip of the peristaltic pump
Implementation Method 2
a temperature control device for regulating and controlling the temperature of the front chamber is comprised in the rear chamber of the cabinet
Implementation Method 3
the collection bottle comprises multiple independent chambers and the outside thereof is coated with a collection bottle heating wire
Implementation Method 4
the carbon dioxide gas bottle is connected to the shunting bottle in the cabinet through a carbon dioxide gas tube
Implementation Method 5
the microscope objective lens is mounted on the microscope stand under the microscope stage; the CCD image sensor is mounted on the microscope stand under the microscope objective lens
Data Source
AI summary
A method of using a device for conducting a vascular hemodynamic bionic cell experiment is provided, the method comprises: firstly, experiment preparation; and secondly, experiment operation, namely, switching on a peristaltic pump, pumping a circulation liquid from a collection bottle into an independently corresponding shunting chamber of a corresponding shunting bottle through a collection bottle sampling tube of an independent chamber of a collection bottle, after shunting by the shunting chamber of the shunting bottle, the circulation liquid flowing out of a branch shunting tube flows to a corresponding flow chamber on the 1-3 flow chamber platforms placed side by side, and then converging the circulation liquid to a corresponding independent chamber of the collection bottle through respective sampling tubes of the flow chamber platforms. The method provided by the present disclosure has the technical characteristics of strong practicability and low manufacturing cost, and can perform a vascular hemodynamic bionic cell experiment under multiple conditions with multiple parameters when used in combination with different models of shunting bottles and flow chamber platforms.