3D Vascular Model Reconstruction from 2D Angiograms
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Solution Overview
Problem
Current methods for diagnosing and treating vascular diseases, such as atherosclerosis, rely heavily on invasive procedures and 2D imaging, which lack functional information and increase patient risk, while 3D fluid flow information is not directly derivable from widely available 2D coronary angiogram data.
Innovation Solution
A system and method for generating a three-dimensional fluid flow simulation of biological structures, such as coronary arteries, by acquiring 2D images, segmenting data, generating 3D geometries, and applying computational fluid dynamics to create a 3D reconstruction, enabling the derivation of fluid quantities like velocity, vorticity, and pressure, and generating a 3D wall shear stress map.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If 2D coronary angiograms are used for diagnosis, then wide availability and ease of acquisition are achieved, but 3D fluid flow information cannot be derived
Solution Approach 1:
The patent applies dimensionality change by transforming 2D angiogram images into 3D vascular models. The system uses multiple 2D angiographic views taken at different angles to reconstruct three-dimensional geometries of coronary vessels, enabling derivation of 3D fluid flow information from traditionally 2D data without requiring additional invasive imaging procedures.
2Measurement precision
If invasive procedures are used for vascular disease diagnosis, then detailed vascular information is obtained, but patient risk increases
Solution Approach 1:
The patent creates virtual 3D copies of the vascular system using computational modeling techniques. Instead of performing invasive procedures to obtain detailed vascular information, the system generates accurate 3D geometric models and fluid dynamics simulations from non-invasive 2D angiogram data, providing detailed vascular information without exposing patients to procedural risks.
3Reliability
If 3D reconstructions are obtained from intravascular ultrasound, then fluid dynamics simulation capability is achieved, but the method is used in only a fraction of invasive studies
Solution Approach 1:
The patent makes fluid dynamics simulation universally applicable by developing a system that works with widely available 2D angiogram data from routine clinical practice. Instead of requiring specialized intravascular ultrasound procedures, the system can process standard angiographic images, making advanced fluid dynamics analysis accessible to a much broader patient population without requiring additional invasive studies.
Data Source
AI summary
Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.